Evidence map›Paper›PMID 32611709›Full record

ArticleRNA (New York, N.Y.)2020

Structure-seq2 probing of RNA structure upon amino acid starvation reveals both known and novel RNA switches in

Laura E Ritchey, David C Tack, Helen Yakhnin, Elizabeth A Jolley, Sarah M Assmann, Philip C Bevilacqua, Paul Babitzke

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Optimized tRNA structure-seq reveals robust tRNA secondary structures inbioRxiv : the preprint server for biology · 2026
    Article
  2. RNA Structure: Past, Future, and Gene Therapy Applications.International journal of molecular sciences · 2024
    Review
  3. In vivo structure probing of RNA inRNA (New York, N.Y.) · 2023
    Article
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  12. Review
  13. Article
  14. Small RNA Profiling inFrontiers in microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Laura E RitcheyDepartment of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
David C TackDepartment of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Helen YakhninDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Elizabeth A JolleyDepartment of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Sarah M AssmannDepartment of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Philip C BevilacquaDepartment of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Paul BabitzkeDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Pennsylvania State University · US

Funding

Regulation of transcription elongationR01GM098399 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BABITZKE, PAUL L · 2012 to 2024
$3.6M
RNA folding and catalysis at the interface of biophysics and genomicsR35GM127064 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PHILIP C BEVILACQUA · 2018 to 2026
$3.4M
RNA thermometers and their role in regulating Bacillus subtilis gene expressionF32GM128311 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI JOLLEY, ELIZABETH · 2018 to 2021
$176k
NIGMS NIH HHS F32 GM128311NIGMS NIH HHS R01 GM098399NIGMS NIH HHS R35 GM127064
6 · The paper itself

Abstract

RNA structure influences numerous processes in all organisms. In bacteria, these processes include transcription termination and attenuation, small RNA and protein binding, translation initiation, and mRNA stability, and can be regulated via metabolite availability and other stresses. Here we use Structure-seq2 to probe the in vivo RNA structurome of

Indexed as

Amino AcidsBacillus subtilisBacterial ProteinsGene Expression Regulation, BacterialNucleic Acid ConformationRNA, BacterialRNA StabilityTranscription, GeneticTranscriptomeAmino AcidsBacterial ProteinsRNA, Bacterialamino acid starvationriboswitchRNA structurestress responsetranscription attenuationtranslation control

Identifiers

PMID32611709
PMCPMC7491331
OpenAlexW3040117817

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.