ArticleNeurology2020
Prevalence of MRI abnormalities in people with epilepsy in rural China.
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Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
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3 citing papers in PubMed, 13 citations in OpenAlex.
- Age-specific MRI patterns in pediatric epilepsy: insights from a sudanese cohort and implications for low-resources settings.BMC medical imaging · 2026Article
- Epilepsy awareness among physicians in plains and plateau regions of western China: a cross-sectional study.Acta epileptologica · 2026Article
- Big data research is everyone's research-Making epilepsy data science accessible to the global community: Report of the ILAE big data commission.Epileptic disorders : international epilepsy journal with videotape · 2024Review
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Authors and funding
12 authors at 1 institution in 2 countries.
Indran DavagnanamFrom the Academic Department of Neuroradiology (I.D.), Department of Brain Repair and Rehabilitation, and NIHR University College London Hospitals (J.S.D., J.W.S.), Biomedical Research Centre, UCL Queen Square Institute of Neurology, London, UK; Clinical Epidemiology (Z.C.), School of Public Health and Preventive Medicine, and Department of Neuroscience (Z.C., P.K.), Central Clinical School, Monash University, Melbourne; Department of Medicine (Z.C., P.K.), Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Lysholm Department of Neuroradiology (C.H.), National Hospital for Neurology & Neurosurgery, Queen Square, London, UK; Institute of Neurology (D.D.), Huashan Hospital, Fudan University, Shanghai; Beijing Neurosurgical Institute (W.W.); Jiaozuo People's Hospital (B.Y.), Henan Province; Ningxia Medical University (Y.W.); Jincheng Emergency Medical Rescue Center (T.W.), Shanxi Province; Affiliated Second Hospital (W.L.), Hebei Medical University, China; Chalfont Centre for Epilepsy (J.S.D., J.W.S.), Chalfont St. Peter, UK; and Stichting Epilepsie Instellingen Nederland (J.W.S.), Heemstede, Netherlands.
Zhibin ChenFrom the Academic Department of Neuroradiology (I.D.), Department of Brain Repair and Rehabilitation, and NIHR University College London Hospitals (J.S.D., J.W.S.), Biomedical Research Centre, UCL Queen Square Institute of Neurology, London, UK; Clinical Epidemiology (Z.C.), School of Public Health and Preventive Medicine, and Department of Neuroscience (Z.C., P.K.), Central Clinical School, Monash University, Melbourne; Department of Medicine (Z.C., P.K.), Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Lysholm Department of Neuroradiology (C.H.), National Hospital for Neurology & Neurosurgery, Queen Square, London, UK; Institute of Neurology (D.D.), Huashan Hospital, Fudan University, Shanghai; Beijing Neurosurgical Institute (W.W.); Jiaozuo People's Hospital (B.Y.), Henan Province; Ningxia Medical University (Y.W.); Jincheng Emergency Medical Rescue Center (T.W.), Shanxi Province; Affiliated Second Hospital (W.L.), Hebei Medical University, China; Chalfont Centre for Epilepsy (J.S.D., J.W.S.), Chalfont St. Peter, UK; and Stichting Epilepsie Instellingen Nederland (J.W.S.), Heemstede, Netherlands.ORCID 0000-0002-1888-6917
Chandrashekar HoskoteFrom the Academic Department of Neuroradiology (I.D.), Department of Brain Repair and Rehabilitation, and NIHR University College London Hospitals (J.S.D., J.W.S.), Biomedical Research Centre, UCL Queen Square Institute of Neurology, London, UK; Clinical Epidemiology (Z.C.), School of Public Health and Preventive Medicine, and Department of Neuroscience (Z.C., P.K.), Central Clinical School, Monash University, Melbourne; Department of Medicine (Z.C., P.K.), Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Lysholm Department of Neuroradiology (C.H.), National Hospital for Neurology & Neurosurgery, Queen Square, London, UK; Institute of Neurology (D.D.), Huashan Hospital, Fudan University, Shanghai; Beijing Neurosurgical Institute (W.W.); Jiaozuo People's Hospital (B.Y.), Henan Province; Ningxia Medical University (Y.W.); Jincheng Emergency Medical Rescue Center (T.W.), Shanxi Province; Affiliated Second Hospital (W.L.), Hebei Medical University, China; Chalfont Centre for Epilepsy (J.S.D., J.W.S.), Chalfont St. Peter, UK; and Stichting Epilepsie Instellingen Nederland (J.W.S.), Heemstede, Netherlands.
Ding DingFrom the Academic Department of Neuroradiology (I.D.), Department of Brain Repair and Rehabilitation, and NIHR University College London Hospitals (J.S.D., J.W.S.), Biomedical Research Centre, UCL Queen Square Institute of Neurology, London, UK; Clinical Epidemiology (Z.C.), School of Public Health and Preventive Medicine, and Department of Neuroscience (Z.C., P.K.), Central Clinical School, Monash University, Melbourne; Department of Medicine (Z.C., P.K.), Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Lysholm Department of Neuroradiology (C.H.), National Hospital for Neurology & Neurosurgery, Queen Square, London, UK; Institute of Neurology (D.D.), Huashan Hospital, Fudan University, Shanghai; Beijing Neurosurgical Institute (W.W.); Jiaozuo People's Hospital (B.Y.), Henan Province; Ningxia Medical University (Y.W.); Jincheng Emergency Medical Rescue Center (T.W.), Shanxi Province; Affiliated Second Hospital (W.L.), Hebei Medical University, China; Chalfont Centre for Epilepsy (J.S.D., J.W.S.), Chalfont St. Peter, UK; and Stichting Epilepsie Instellingen Nederland (J.W.S.), Heemstede, Netherlands.
Bin YangFrom the Academic Department of Neuroradiology (I.D.), Department of Brain Repair and Rehabilitation, and NIHR University College London Hospitals (J.S.D., J.W.S.), Biomedical Research Centre, UCL Queen Square Institute of Neurology, London, UK; Clinical Epidemiology (Z.C.), School of Public Health and Preventive Medicine, and Department of Neuroscience (Z.C., P.K.), Central Clinical School, Monash University, Melbourne; Department of Medicine (Z.C., P.K.), Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Lysholm Department of Neuroradiology (C.H.), National Hospital for Neurology & Neurosurgery, Queen Square, London, UK; Institute of Neurology (D.D.), Huashan Hospital, Fudan University, Shanghai; Beijing Neurosurgical Institute (W.W.); Jiaozuo People's Hospital (B.Y.), Henan Province; Ningxia Medical University (Y.W.); Jincheng Emergency Medical Rescue Center (T.W.), Shanxi Province; Affiliated Second Hospital (W.L.), Hebei Medical University, China; Chalfont Centre for Epilepsy (J.S.D., J.W.S.), Chalfont St. Peter, UK; and Stichting Epilepsie Instellingen Nederland (J.W.S.), Heemstede, Netherlands.
Yingli WangFrom the Academic Department of Neuroradiology (I.D.), Department of Brain Repair and Rehabilitation, and NIHR University College London Hospitals (J.S.D., J.W.S.), Biomedical Research Centre, UCL Queen Square Institute of Neurology, London, UK; Clinical Epidemiology (Z.C.), School of Public Health and Preventive Medicine, and Department of Neuroscience (Z.C., P.K.), Central Clinical School, Monash University, Melbourne; Department of Medicine (Z.C., P.K.), Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Lysholm Department of Neuroradiology (C.H.), National Hospital for Neurology & Neurosurgery, Queen Square, London, UK; Institute of Neurology (D.D.), Huashan Hospital, Fudan University, Shanghai; Beijing Neurosurgical Institute (W.W.); Jiaozuo People's Hospital (B.Y.), Henan Province; Ningxia Medical University (Y.W.); Jincheng Emergency Medical Rescue Center (T.W.), Shanxi Province; Affiliated Second Hospital (W.L.), Hebei Medical University, China; Chalfont Centre for Epilepsy (J.S.D., J.W.S.), Chalfont St. Peter, UK; and Stichting Epilepsie Instellingen Nederland (J.W.S.), Heemstede, Netherlands.
Taiping WangFrom the Academic Department of Neuroradiology (I.D.), Department of Brain Repair and Rehabilitation, and NIHR University College London Hospitals (J.S.D., J.W.S.), Biomedical Research Centre, UCL Queen Square Institute of Neurology, London, UK; Clinical Epidemiology (Z.C.), School of Public Health and Preventive Medicine, and Department of Neuroscience (Z.C., P.K.), Central Clinical School, Monash University, Melbourne; Department of Medicine (Z.C., P.K.), Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Lysholm Department of Neuroradiology (C.H.), National Hospital for Neurology & Neurosurgery, Queen Square, London, UK; Institute of Neurology (D.D.), Huashan Hospital, Fudan University, Shanghai; Beijing Neurosurgical Institute (W.W.); Jiaozuo People's Hospital (B.Y.), Henan Province; Ningxia Medical University (Y.W.); Jincheng Emergency Medical Rescue Center (T.W.), Shanxi Province; Affiliated Second Hospital (W.L.), Hebei Medical University, China; Chalfont Centre for Epilepsy (J.S.D., J.W.S.), Chalfont St. Peter, UK; and Stichting Epilepsie Instellingen Nederland (J.W.S.), Heemstede, Netherlands.
Wenling LiFrom the Academic Department of Neuroradiology (I.D.), Department of Brain Repair and Rehabilitation, and NIHR University College London Hospitals (J.S.D., J.W.S.), Biomedical Research Centre, UCL Queen Square Institute of Neurology, London, UK; Clinical Epidemiology (Z.C.), School of Public Health and Preventive Medicine, and Department of Neuroscience (Z.C., P.K.), Central Clinical School, Monash University, Melbourne; Department of Medicine (Z.C., P.K.), Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Lysholm Department of Neuroradiology (C.H.), National Hospital for Neurology & Neurosurgery, Queen Square, London, UK; Institute of Neurology (D.D.), Huashan Hospital, Fudan University, Shanghai; Beijing Neurosurgical Institute (W.W.); Jiaozuo People's Hospital (B.Y.), Henan Province; Ningxia Medical University (Y.W.); Jincheng Emergency Medical Rescue Center (T.W.), Shanxi Province; Affiliated Second Hospital (W.L.), Hebei Medical University, China; Chalfont Centre for Epilepsy (J.S.D., J.W.S.), Chalfont St. Peter, UK; and Stichting Epilepsie Instellingen Nederland (J.W.S.), Heemstede, Netherlands.
John S DuncanFrom the Academic Department of Neuroradiology (I.D.), Department of Brain Repair and Rehabilitation, and NIHR University College London Hospitals (J.S.D., J.W.S.), Biomedical Research Centre, UCL Queen Square Institute of Neurology, London, UK; Clinical Epidemiology (Z.C.), School of Public Health and Preventive Medicine, and Department of Neuroscience (Z.C., P.K.), Central Clinical School, Monash University, Melbourne; Department of Medicine (Z.C., P.K.), Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Lysholm Department of Neuroradiology (C.H.), National Hospital for Neurology & Neurosurgery, Queen Square, London, UK; Institute of Neurology (D.D.), Huashan Hospital, Fudan University, Shanghai; Beijing Neurosurgical Institute (W.W.); Jiaozuo People's Hospital (B.Y.), Henan Province; Ningxia Medical University (Y.W.); Jincheng Emergency Medical Rescue Center (T.W.), Shanxi Province; Affiliated Second Hospital (W.L.), Hebei Medical University, China; Chalfont Centre for Epilepsy (J.S.D., J.W.S.), Chalfont St. Peter, UK; and Stichting Epilepsie Instellingen Nederland (J.W.S.), Heemstede, Netherlands.
Wenzhi WangFrom the Academic Department of Neuroradiology (I.D.), Department of Brain Repair and Rehabilitation, and NIHR University College London Hospitals (J.S.D., J.W.S.), Biomedical Research Centre, UCL Queen Square Institute of Neurology, London, UK; Clinical Epidemiology (Z.C.), School of Public Health and Preventive Medicine, and Department of Neuroscience (Z.C., P.K.), Central Clinical School, Monash University, Melbourne; Department of Medicine (Z.C., P.K.), Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Lysholm Department of Neuroradiology (C.H.), National Hospital for Neurology & Neurosurgery, Queen Square, London, UK; Institute of Neurology (D.D.), Huashan Hospital, Fudan University, Shanghai; Beijing Neurosurgical Institute (W.W.); Jiaozuo People's Hospital (B.Y.), Henan Province; Ningxia Medical University (Y.W.); Jincheng Emergency Medical Rescue Center (T.W.), Shanxi Province; Affiliated Second Hospital (W.L.), Hebei Medical University, China; Chalfont Centre for Epilepsy (J.S.D., J.W.S.), Chalfont St. Peter, UK; and Stichting Epilepsie Instellingen Nederland (J.W.S.), Heemstede, Netherlands.
Josemir W SanderFrom the Academic Department of Neuroradiology (I.D.), Department of Brain Repair and Rehabilitation, and NIHR University College London Hospitals (J.S.D., J.W.S.), Biomedical Research Centre, UCL Queen Square Institute of Neurology, London, UK; Clinical Epidemiology (Z.C.), School of Public Health and Preventive Medicine, and Department of Neuroscience (Z.C., P.K.), Central Clinical School, Monash University, Melbourne; Department of Medicine (Z.C., P.K.), Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Lysholm Department of Neuroradiology (C.H.), National Hospital for Neurology & Neurosurgery, Queen Square, London, UK; Institute of Neurology (D.D.), Huashan Hospital, Fudan University, Shanghai; Beijing Neurosurgical Institute (W.W.); Jiaozuo People's Hospital (B.Y.), Henan Province; Ningxia Medical University (Y.W.); Jincheng Emergency Medical Rescue Center (T.W.), Shanxi Province; Affiliated Second Hospital (W.L.), Hebei Medical University, China; Chalfont Centre for Epilepsy (J.S.D., J.W.S.), Chalfont St. Peter, UK; and Stichting Epilepsie Instellingen Nederland (J.W.S.), Heemstede, Netherlands.ORCID 0000-0001-6041-9661
Patrick KwanFrom the Academic Department of Neuroradiology (I.D.), Department of Brain Repair and Rehabilitation, and NIHR University College London Hospitals (J.S.D., J.W.S.), Biomedical Research Centre, UCL Queen Square Institute of Neurology, London, UK; Clinical Epidemiology (Z.C.), School of Public Health and Preventive Medicine, and Department of Neuroscience (Z.C., P.K.), Central Clinical School, Monash University, Melbourne; Department of Medicine (Z.C., P.K.), Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Lysholm Department of Neuroradiology (C.H.), National Hospital for Neurology & Neurosurgery, Queen Square, London, UK; Institute of Neurology (D.D.), Huashan Hospital, Fudan University, Shanghai; Beijing Neurosurgical Institute (W.W.); Jiaozuo People's Hospital (B.Y.), Henan Province; Ningxia Medical University (Y.W.); Jincheng Emergency Medical Rescue Center (T.W.), Shanxi Province; Affiliated Second Hospital (W.L.), Hebei Medical University, China; Chalfont Centre for Epilepsy (J.S.D., J.W.S.), Chalfont St. Peter, UK; and Stichting Epilepsie Instellingen Nederland (J.W.S.), Heemstede, Netherlands patrick.kwan@monash.edu.
Institute of Ophthalmology · MX
Funding
Validation of clinical assessment tools for population genetic studies of epilepsR21NS069223 · NINDS · CHINESE UNIVERSITY OF HONG KONG · PI BAUM, LAWRENCE, CHERNY, STACEY S · 2010 to 2011
$272kDepartment of HealthNINDS NIH HHS R21 NS069223
Abstract
objectiveTo assess the prevalence of brain MRI abnormalities in people with epilepsy in rural China and to compare it with that of individuals in the United Kingdom.
methodsBrain MRI scans were obtained in people with epilepsy who participated in a rural community-based program in China between July 2010 and December 2012. Individual epileptogenic lesion types were reviewed and their associations with seizure control examined. The MRI findings were compared with 2 previous similar studies in the United Kingdom.
resultsAmong the 597 individuals (58% male, median age 38 years) with MRI scans analyzed, 488 (82%) had active epilepsy. The MRI was abnormal in 389 individuals (65%), with potentially epileptogenic lesion in 224 (38%) and nonspecific abnormalities in 165 (28%), and 108 (18%) were potentially resectable. The potentially epileptogenic lesions were less frequently detected in children (<18 years old, 12 of 68, 18%) than in adults (212 of 529, 40%;
conclusionsMore than one-third of people with chronic epilepsy in rural China have potentially epileptogenic lesions identifiable on brain MRI, with two-thirds fulfilling the definition of pharmacoresistance. These findings highlight the magnitude of the unmet needs for epilepsy surgery in China.
Indexed as
AdolescentAdultAgedAged, 80 and overBrain NeoplasmsCentral Nervous System Vascular MalformationsChildChild, PreschoolChinaDrug Resistant EpilepsyEncephalomalaciaEpilepsyFemaleGliosisHumansMagnetic Resonance Imaging
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