Evidence map›Paper›PMID 32611549›Full record

ArticleLife science alliance2020

Structure of avian influenza hemagglutinin in complex with a small molecule entry inhibitor.

Aleksandar Antanasijevic, Matthew A Durst, Han Cheng, Irina N Gaisina, Jasmine T Perez, Balaji Manicassamy, Lijun Rong, Arnon Lavie, Michael Caffrey

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Journal of medicinal chemistry · 2025
    Article
  2. Mechanistic insights into the small-molecule inhibition of influenza A virus entry.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Small Molecule Inhibitors of Influenza Virus Entry.Pharmaceuticals (Basel, Switzerland) · 2021
    Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Aleksandar AntanasijevicDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL, USA.
Matthew A DurstDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL, USA.ORCID 0000-0001-9513-2361
Han ChengDepartment of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL, USA.
Irina N GaisinaChicago BioSolutions, Inc., Chicago, IL, USA.ORCID 0000-0002-8668-3222
Jasmine T PerezDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.
Balaji ManicassamyDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.
Lijun RongDepartment of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL, USA.ORCID 0000-0003-3938-0445
Arnon LavieDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL, USA.
Michael CaffreyDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL, USA caffrey@uic.edu.ORCID 0000-0002-6119-1336
University of Illinois Chicago · USUniversity of Iowa · US

Funding

ENDOTHELIAL CELL TROPISM IN THE PATHOGENESIS AND HOST RESPONSE AGAINST INFLUENZA VIRUSES - RESUBMISSION 01R01AI127775 · NIAID · UNIVERSITY OF IOWA · PI MANICASSAMY, BALAJI · 2018 to 2022
$2.8M
Modulation of Influenza Virus Replication and Fitness by Adenosine DeaminasesR01AI123359 · NIAID · UNIVERSITY OF IOWA · PI MANICASSAMY, BALAJI · 2016 to 2020
$1.9M
Development of group 2 influenza A virus entry inhibitorsR41AI145727 · NIAID · CHICAGO BIOSOLUTIONS, INC. · PI RONG, LIJUN · 2019 to 2020
$600k
4-Aminopiperidines as novel anti-influenza agentsR41AI127031 · NIAID · CHICAGO BIOSOLUTIONS, INC. · PI RONG, LIJUN · 2016 to 2017
$396k
NIAID NIH HHS R01 AI123359NIAID NIH HHS R01 AI127775NIAID NIH HHS R41 AI127031NIAID NIH HHS R41 AI145727
6 · The paper itself

Abstract

HA plays a critical role in influenza infection and, thus HA is a potential target for antivirals. Recently, our laboratories have described a novel fusion inhibitor, termed CBS1117, with EC

Indexed as

AnimalsAntiviral AgentsBinding SitesBirdsCrystallography, X-RayHemagglutinin Glycoproteins, Influenza VirusHemagglutininsHumansInfluenza A Virus, H5N1 SubtypeInfluenza, HumanInfluenza in BirdsModels, MolecularOrthomyxoviridae InfectionsVirus InternalizationAntiviral AgentsHemagglutinin Glycoproteins, Influenza VirusHemagglutinins

Identifiers

PMID32611549
PMCPMC7335401
OpenAlexW3040274149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.