Evidence map›Paper›PMID 32611445›Full record

ArticleTrials2020

TILT: Time-Lapse Imaging Trial-a pragmatic, multi-centre, three-arm randomised controlled trial to assess the clinical effectiveness and safety of time-lapse imaging in in vitro fertilisation treatment.

Priya Bhide, Arasaratnam Srikantharajah, Doris Lanz, Julie Dodds, Bonnie Collins, Javier Zamora, David Chan, Shakila Thangaratinam, Khalid S Khan

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Automation in ART: Paving the Way for the Future of Infertility Treatment.Reproductive sciences (Thousand Oaks, Calif.) · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Priya BhideBarts Research Centre for Women's Health, Institute of Population Health Sciences, Queen Mary University of London, London, UK. p.bhide@qmul.ac.uk.ORCID http://orcid.org/0000-0003-0871-6508
Arasaratnam SrikantharajahHomerton Fertility Centre, Homerton University Hospital, London, UK.
Doris LanzBarts Research Centre for Women's Health, Institute of Population Health Sciences, Queen Mary University of London, London, UK.
Julie DoddsBarts Research Centre for Women's Health, Institute of Population Health Sciences, Queen Mary University of London, London, UK.
Bonnie CollinsCentre for Reproductive Medicine, St Bartholomew's Hospital, London, UK.
Javier ZamoraBarts Research Centre for Women's Health, Institute of Population Health Sciences, Queen Mary University of London, London, UK.
David ChanAssisted Reproductive Technology Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR.
Shakila ThangaratinamInstitute of Metabolism and Systems Research, WHO Collaborating Centre for Women's Health, University of Birmingham, Birmingham, UK.
Khalid S KhanDepartment of Preventive Medicine and Public Health, University of Granada, Granada, Spain.

Funding

Barts Charity MGU0374
6 · The paper itself

Abstract

backgroundSubfertility is a common problem for which in vitro fertilisation (IVF) treatment is commonly recommended. Success rates following IVF are suboptimal and have remained static over the last few years. This imposes a considerable financial burden on overstretched healthcare resources. Time-lapse imaging (TLI) of developing embryos in IVF treatment is hypothesised to improve the success rates of treatment. This may be either by providing undisturbed culture conditions or by improving the predictive accuracy for optimal embryo selection from a cohort of available embryos. However, the current best evidence for its effectiveness is inconclusive.

methodsThe time-lapse imaging trial is a pragmatic, multi-centre, three-arm parallel-group randomised controlled trial using re-randomisation. The primary objective of the trial is to determine if the use of TLI or undisturbed culture in IVF treatment results in a higher live birth rate when compared to current standard methods of embryo incubation and assessment. Secondary outcomes include measures of clinical efficacy and safety. The trial will randomise 1575 participants to detect an increase in live birth from 26.5 to 35.25%. DISCUSSION: In the absence of high-quality evidence, there is no current national guidance, recommendation or policy for the use of TLI. The use of TLI is not consistently incorporated into standard IVF care. A large, pragmatic, multi-centre, trial will provide much needed definitive evidence regarding the effectiveness of TLI. If proven to be effective, its incorporation into standard care would translate into significant clinical and economic benefits. If not, it would allow allocation of resources to more effective interventions.

trial registrationISRCTN registry ISRCTN17792989 . Prospectively registered on 18 April 2018.

Indexed as

Embryo Culture TechniquesFertilization in VitroEmbryonic DevelopmentFemaleHumansLive BirthMulticenter Studies as TopicPragmatic Clinical Trials as TopicPregnancyPregnancy RateTime-Lapse ImagingTreatment OutcomeAssisted conceptionFertilityIn vitro fertilisationLive birthTime-lapse imaging

Identifiers

PMID32611445
PMCPMC7329433

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.