ArticleParticle and fibre toxicology2020
Serum-borne factors alter cerebrovascular endothelial microRNA expression following particulate matter exposure near an abandoned uranium mine on the Navajo Nation.
Article in Particle and fibre toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Impact of air pollution and occupational inhalation exposures on neurodegenerative disorders: An epigenetic perspective.iScience · 2025Review
- Unraveling the mechanisms underlying air pollution-induced dysfunction of the oral-gut-brain axis: implications for human health and well-being.Asian biomedicine : research, reviews and news · 2025Review
- Effects of particulate air pollution exposure on lung-brain axis and related miRNAs modulation in mouse models.Frontiers in cell and developmental biology · 2025Review
- Mechanistic insights regarding neuropsychiatric and neuropathologic impacts of air pollution.Critical reviews in toxicology · 2024Review
- Review
- Systemic immunological responses are dependent on sex and ovarian hormone presence following acute inhaled woodsmoke exposure.Particle and fibre toxicology · 2024Article
- Alzheimer's disease and its related dementias in US Native Americans: A major public health concern.Ageing research reviews · 2023Review
- Acute inhalation of tungsten particles results in early signs of cardiac injury.Toxicology letters · 2023Article
- Lung-Based, Exosome Inhibition Mediates Systemic Impacts Following Particulate Matter Exposure.Toxics · 2022Article
- VCAM-1 Is Upregulated in Uranium Miners Compared to Other Miners.Life (Basel, Switzerland) · 2021Article
- Mine-site derived particulate matter exposure exacerbates neurological and pulmonary inflammatory outcomes in an autoimmune mouse model.Journal of toxicology and environmental health. Part A · 2021Article
- CRISPR/Cas9-Mediated Whole Genomic Wide Knockout Screening Identifies Specific Genes Associated With PMFrontiers in bioengineering and biotechnology · 2021Article
- What does dementia mean to you? Perceptions of dementia and aging among Indigenous older adults living in a Pueblo community.Journal of Alzheimer's disease reportsArticle
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCommercial uranium mining on the Navajo Nation has subjected communities on tribal lands in the Southwestern United States to exposures from residual environmental contamination. Vascular health effects from these ongoing exposures are an active area of study. There is an association between residential mine-site proximity and circulating biomarkers in residents, however, the contribution of mine-site derived wind-blown dusts on vascular and other health outcomes is unknown. To assess neurovascular effects of mine-site derived dusts, we exposed mice using a novel exposure paradigm, the AirCARE1 mobile inhalation laboratory, located 2 km from an abandoned uranium mine, Claim 28 in Blue Gap Tachee, AZ. Mice were exposed to filtered air (FA) (n = 6) or concentrated ambient particulate matter (CAPs) (n = 5) for 2 wks for 4 h per day.
resultsTo assess miRNA differential expression in cultured mouse cerebrovascular cells following particulate matter (PM) exposure (average: 96.6 ± 60.4 μg/m
conclusionsOur data suggest that mCEC miRNAs as measured in the SCIP assay show similarity to serum-borne miRNAs, as approximately 30% of highly differentially expressed cellular miRNAs in the SCIP assay were also found in the serum. While translocation of miRNAs via exosomes or an alternative mechanism is certainly possible, other yet-to-be-identified factors in the serum may be responsible for significant miRNA differential expression in endothelium following inhaled exposures. Additionally, the most highly upregulated murine miRNAs in the CAPs exposure group were in the let-7a family. These miRNAs play a prominent role in cell growth and differentiation and based on our transfection experiments, mmu-let-7a may contribute to cerebrovascular mCEC alterations following inhaled dust exposure.
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