ArticleBMC palliative care2020
Hypernatremia at admission predicts poor survival in patients with terminal cancer: a retrospective cohort study.
Article in BMC palliative care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Multiple electrolyte imbalances in hospitalized patients: a multimorbidity perspective from a large, retrospective cohort study.Annals of medicine · 2026Article
- Association between preoperative serum sodium and postoperative 30-day mortality in adult patients with tumor craniotomy.BMC neurology · 2023Article
- Chapter 1: Evaluation of kidney function in patients undergoing anticancer drug therapy, from clinical practice guidelines for the management of kidney injury during anticancer drug therapy 2022.International journal of clinical oncology · 2023Review
- Hypernatremia: Epidemiology and Predictive Role in Emerging and Established Acute Kidney Injury.Journal of clinical medicine research · 2023Review
- Outcome of Hospitalized Cancer Patients with Hypernatremia: A Retrospective Case-Control Study.Current oncology (Toronto, Ont.) · 2022Article
- Molecular and physical technologies for monitoring fluid and electrolyte imbalance: A focus on cancer population.Clinical and translational medicine · 2021Review
- Symptoms, Electrolyte Disturbances and Serum Albumin Levels in Palliative Oncology Patients Admitted Through Emergency: Characteristics and Survival Outcomes.Indian journal of palliative careArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlthough palliative care providers, patients, and their families rely heavily on accurate prognostication, the prognostic value of electrolyte imbalance has received little attention.
methodsAs a retrospective review, we screened inpatients with terminal cancer admitted between January 2017 and May 2019 to a single hospice-palliative care unit. Clinical characteristics and laboratory results were obtained from medical records for multivariable Cox regression analysis of independent prognostic factors.
resultsOf the 487 patients who qualified, 15 (3%) were hypernatremic upon admission. The median survival time was 26 days. Parameters associated with shortened survival included male sex, advanced age (> 70 years), lung cancer, poor performance status, elevated inflammatory markers, azotemia, impaired liver function, and hypernatremia. In a multivariable Cox proportional hazards model, male sex (hazard ratio [HR] = 1.53, 95% confidence interval [CI]: 1.15-2.04), poor performance status (HR = 1.45, 95% CI: 1.09-1.94), leukocytosis (HR = 1.98, 95% CI: 1.47-2.66), hypoalbuminemia (HR = 2.06, 95% CI: 1.49-2.73), and hypernatremia (HR = 1.55, 95% CI: 1.18-2.03) emerged as significant predictors of poor prognosis.
conclusionHypernatremia may be a useful gauge of prognosis in patients with terminal cancer. Further large-scale prospective studies are needed to corroborate this finding.
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