Evidence map›Paper›PMID 32611306›Full record

ArticleGenetics, selection, evolution : GSE2020

Highly efficient generation of sheep with a defined FecB

Shiwei Zhou, Yige Ding, Jiao Liu, Yao Liu, Xiaoe Zhao, Guanwei Li, Chenguang Zhang, Chao Li, Ying Wang, Peter Kalds and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics, selection, evolution : GSE, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Molecular therapy. Nucleic acids · 2025
    Review
  3. Optimization of CRISPR/Cas9 Gene Editing System in Sheep (International journal of molecular sciences · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Two Retrotransposon Elements in Intron of PorcineLife (Basel, Switzerland) · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 2 countries.

Shiwei ZhouKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Yige DingKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Jiao LiuKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Yao LiuKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Xiaoe ZhaoCollege of Veterinary Medicine, Northwest A&F University, Yangling, China.
Guanwei LiKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Chenguang ZhangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Chao LiKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Ying WangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Peter KaldsKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Yawei GaoKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Bo ZongKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Xiaoyu HuangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Shuhong HuangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Honghao YuCollege of Biotechnology, Guilin Medical University, Guilin, China.
Qifang KouNingxia Tianyuan Tan Sheep Farm, Hongsibu, China.
Bjoern PetersenInstitute of Farm Animal Genetics, Friedrich-Loeffler-Institut, Neustadt, Germany.
Xingxu HuangSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Xiaolong WangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China. xiaolongwang@nwafu.edu.cn.ORCID http://orcid.org/0000-0003-1620-1344
Baohua MaCollege of Veterinary Medicine, Northwest A&F University, Yangling, China. mabh@nwafu.edu.cn.
Yulin ChenKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China. chenyulin@nwafu.edu.cn.
Northwest A&F University · CNNorth West Agriculture and Forestry University · CNShanghaiTech University · CNFriedrich-Loeffler-Institut · DEGuilin Medical University · CN

Funding

Local Grants 2018KJXX-009Local Grants NXTS2018-001Local Road Research Board 2017NY-072National Natural Science Foundation of China 31772571
6 · The paper itself

Abstract

Base editing has the potential to improve important economic traits in agriculture and can precisely convert single nucleotides in DNA or RNA sequences into minimal double-strand DNA breaks (DSB). Adenine base editors (ABE) have recently emerged as a base editing tool for the conversion of targeted A:T to G:C, but have not yet been used in sheep. ABEmax is one of the latest versions of ABE, which consists of a catalytically-impaired nuclease and a laboratory-evolved DNA-adenosine deaminase. The Booroola fecundity (FecB

Indexed as

AdenineAdenosine DeaminaseAnimalsBone Morphogenetic Protein Receptors, Type IBreedingFemaleFertilityGene EditingGenetic EngineeringGenotypeHeterozygoteLitter SizeMaleMutationPhenotypePolymorphism, Single NucleotideAdenineAdenosine DeaminaseBone Morphogenetic Protein Receptors, Type I

Identifiers

PMID32611306
PMCPMC7328262
OpenAlexW3039582431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.