Evidence map›Paper›PMID 32611260›Full record

ArticleDrug delivery2020

Biodistribution of etoposide via intratumoral chemotherapy with etoposide-loaded implants.

Chunsheng Wu, Xiangting Yi, Renzhi Xu, Maokuan Zhang, Yan Xu, Yan Ma, Li Gao, Zhengbao Zha

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Chunsheng WuSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, PR China.
Xiangting YiSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, PR China.
Renzhi XuSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, PR China.
Maokuan ZhangLaboratory of Pharmaceutical Research, Anhui Zhongren Science and Technology Co., Ltd, Hefei, PR China.
Yan XuSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, PR China.
Yan MaSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, PR China.
Li GaoSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, PR China.
Zhengbao ZhaSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, PR China.
Hefei University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Etoposide (VP16) is the traditional antitumor agent which has been widely used in a variety of cancers. However, intravenous administration of VP16 was limited in clinical application because of its low aqueous solubility, poor bioavailability and dose-limiting adverse effects. Local chemotherapy with VP16-loaded drug delivery systems could provide a continuous release of drug at the target site, while minimizing the systemic toxicity. In this study, we prepared the poly-l-lactic acid (PLLA) based VP16-loaded implants (VP16 implants) by the direct compression method. The VP16 implants were characterized with regards to drug content, micromorphology, drug release profiles, differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR) analyses. Furthermore, the biodistribution of VP16 via intratumoral chemotherapy with VP16 implants was investigated using the murine Lewis lung carcinoma model. Our results showed that VP16 dispersed homogenously in the polymeric matrix. Both

Indexed as

AnimalsAntineoplastic AgentsCalorimetry, Differential ScanningCell Line, TumorDrug ImplantsDrug LiberationEtoposideMicePolyestersRatsRats, WistarSpectroscopy, Fourier Transform InfraredTechnology, PharmaceuticalTissue DistributionAntineoplastic AgentsDrug ImplantsEtoposidePolyesterspoly(lactide)biodistributionEtoposideimplantsintratumoral chemotherapyPLLA

Identifiers

PMID32611260
PMCPMC8216434
OpenAlexW3038912930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.