Evidence map›Paper›PMID 32611257›Full record

ArticleCirculation2020

Calcineurin Aβ-Specific Anchoring Confers Isoform-Specific Compartmentation and Function in Pathological Cardiac Myocyte Hypertrophy.

Xiaofeng Li, Jinliang Li, Eliana C Martinez, Alexander Froese, Catherine L Passariello, Kathryn Henshaw, Francesca Rusconi, Yang Li, Qian Yu, Hrishikesh Thakur and 2 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. A perinuclear calcium compartment regulates cardiac myocyte hypertrophy.Journal of molecular and cellular cardiology · 2022
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Xiaofeng Li *Interdisciplinary Stem Cell Institute, Department of Pediatrics, Leonard M. Miller School of Medicine, University of Miami, FL (X.L., J.L., E.C.M., C.L.P., K.H., F.R., H.T., M.S.K.).
Jinliang Li *Interdisciplinary Stem Cell Institute, Department of Pediatrics, Leonard M. Miller School of Medicine, University of Miami, FL (X.L., J.L., E.C.M., C.L.P., K.H., F.R., H.T., M.S.K.).
Eliana C MartinezInterdisciplinary Stem Cell Institute, Department of Pediatrics, Leonard M. Miller School of Medicine, University of Miami, FL (X.L., J.L., E.C.M., C.L.P., K.H., F.R., H.T., M.S.K.).
Alexander FroeseInstitute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (A.F., V.O.N.).
Catherine L PassarielloInterdisciplinary Stem Cell Institute, Department of Pediatrics, Leonard M. Miller School of Medicine, University of Miami, FL (X.L., J.L., E.C.M., C.L.P., K.H., F.R., H.T., M.S.K.).
Kathryn HenshawInterdisciplinary Stem Cell Institute, Department of Pediatrics, Leonard M. Miller School of Medicine, University of Miami, FL (X.L., J.L., E.C.M., C.L.P., K.H., F.R., H.T., M.S.K.).
Francesca RusconiInterdisciplinary Stem Cell Institute, Department of Pediatrics, Leonard M. Miller School of Medicine, University of Miami, FL (X.L., J.L., E.C.M., C.L.P., K.H., F.R., H.T., M.S.K.).
Yang LiDepartments of Ophthalmology and Medicine, Stanford Cardiovascular Institute, Stanford University, Palo Alto, CA (J.L., Y.L., Q.Y., H.T., M.S.K.).
Qian YuDepartments of Ophthalmology and Medicine, Stanford Cardiovascular Institute, Stanford University, Palo Alto, CA (J.L., Y.L., Q.Y., H.T., M.S.K.).
Hrishikesh ThakurInterdisciplinary Stem Cell Institute, Department of Pediatrics, Leonard M. Miller School of Medicine, University of Miami, FL (X.L., J.L., E.C.M., C.L.P., K.H., F.R., H.T., M.S.K.).
Viacheslav O NikolaevInstitute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (A.F., V.O.N.).
Michael S KapiloffInterdisciplinary Stem Cell Institute, Department of Pediatrics, Leonard M. Miller School of Medicine, University of Miami, FL (X.L., J.L., E.C.M., C.L.P., K.H., F.R., H.T., M.S.K.).
Cardiovascular Institute of the South · USStem Cell Institute · PAUniversität Hamburg · DE

Funding

Training in Myocardial Biology at Stanford (TIMBS)T32HL094274 · NHLBI · STANFORD UNIVERSITY · PI Euan A Ashley, Daniel Bernstein · 2010 to 2026
$5.0M
Regulation of Histone Deacetylases by mAKAP SignalosomesR01HL146111 · NHLBI · STANFORD UNIVERSITY · PI DODGE-KAFKA, KIMBERLY L, KAPILOFF, MICHAEL SETH · 2019 to 2022
$2.2M
The Role of Perinuclear Calcium for The induction of Cardiac HypertrophyR01HL126825 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI DODGE-KAFKA, KIMBERLY L, KAPILOFF, MICHAEL SETH · 2016 to 2019
$1.7M
Role of the F-Bar Protein CIP4 in Cardiac HypertrophyR01HL126950 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI KAPILOFF, MICHAEL SETH · 2016 to 2019
$1.6M
NHLBI NIH HHS R01 HL126825NHLBI NIH HHS R01 HL126950NHLBI NIH HHS R01 HL146111NHLBI NIH HHS T32 HL094274
6 · The paper itself

Abstract

backgroundThe Ca

methodsPrimary adult rat ventricular myocytes were studied for morphology and intracellular signaling. New Förster resonance energy transfer reporters were used to assay Ca

resultsCIP4 (Cdc42-interacting protein 4)/TRIP10 (thyroid hormone receptor interactor 10) was identified as a new polyproline domain-dependent scaffold for CaNAβ2 by yeast 2-hybrid screen. Cardiac myocyte-specific

conclusionsThese results support a structural model for Ca

Indexed as

AnimalsCalcineurinCardiomegalyHeart VentriclesIsoenzymesMiceMice, TransgenicMicrotubule-Associated ProteinsMinor Histocompatibility AntigensMyocytes, CardiacCalcineurinIsoenzymesMicrotubule-Associated ProteinsMinor Histocompatibility Antigensprotein phosphatase 3, catalytic subunit, beta isoform, mouseTrip10 protein, mousecalcineurincalciumcardiomegaly

Identifiers

PMID32611257
PMCPMC7484230
OpenAlexW3039853521

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.