Evidence map›Paper›PMID 32611235›Full record

ArticleCirculation research2020

Hematoma Resolution In Vivo Is Directed by Activating Transcription Factor 1.

Anusha Seneviratne, Yumeng Han, Eunice Wong, Edward R H Walter, Lijun Jiang, Luke Cave, Nicholas J Long, David Carling, Justin C Mason, Dorian O Haskard and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Enzyme-activated probes in optical imaging: a focus on atherosclerosis.Dalton transactions (Cambridge, England : 2003) · 2021
    Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Anusha SeneviratneFrom the National Heart and Lung Institute (A.S., Y.H., E.W., E.R.H.W., L.C., J.C.M., D.O.H., J.J.B.), Imperial College London Hammersmith Campus.
Yumeng HanFrom the National Heart and Lung Institute (A.S., Y.H., E.W., E.R.H.W., L.C., J.C.M., D.O.H., J.J.B.), Imperial College London Hammersmith Campus.
Eunice WongFrom the National Heart and Lung Institute (A.S., Y.H., E.W., E.R.H.W., L.C., J.C.M., D.O.H., J.J.B.), Imperial College London Hammersmith Campus.
Edward R H WalterFrom the National Heart and Lung Institute (A.S., Y.H., E.W., E.R.H.W., L.C., J.C.M., D.O.H., J.J.B.), Imperial College London Hammersmith Campus.
Lijun JiangMolecular Sciences Research Hub, Imperial College London White City Campus (Y.H., E.W., E.R.H.W., L.J., N.J.L.).
Luke CaveFrom the National Heart and Lung Institute (A.S., Y.H., E.W., E.R.H.W., L.C., J.C.M., D.O.H., J.J.B.), Imperial College London Hammersmith Campus.
Nicholas J LongMolecular Sciences Research Hub, Imperial College London White City Campus (Y.H., E.W., E.R.H.W., L.J., N.J.L.).
David CarlingMRC London Institute of Medical Sciences (D.C.), Imperial College London Hammersmith Campus.
Justin C MasonFrom the National Heart and Lung Institute (A.S., Y.H., E.W., E.R.H.W., L.C., J.C.M., D.O.H., J.J.B.), Imperial College London Hammersmith Campus.
Dorian O HaskardFrom the National Heart and Lung Institute (A.S., Y.H., E.W., E.R.H.W., L.C., J.C.M., D.O.H., J.J.B.), Imperial College London Hammersmith Campus.
Joseph J BoyleFrom the National Heart and Lung Institute (A.S., Y.H., E.W., E.R.H.W., L.C., J.C.M., D.O.H., J.J.B.), Imperial College London Hammersmith Campus.
Lung Institute · USImperial College London · GBHammersmith Hospital · GBMRC London Institute of Medical Sciences · GB

Funding

Biotechnology and Biological Sciences Research Council BB/L015129/1British Heart Foundation FS/13/12/30037British Heart Foundation PG/17/71/33242Medical Research Council MC_U120027537Medical Research Council MR/N011775/1Wellcome Trust 104931Wellcome Trust 104931/Z/14/Z
6 · The paper itself

Abstract

rationaleThe efficient resolution of tissue hemorrhage is an important homeostatic function. In human macrophages in vitro, heme activates an AMPK (AMP-activated protein kinase)/ATF1 (activating transcription factor-1) pathway that directs Mhem macrophages through coregulation of HO-1 (heme oxygenase-1;

objectiveWe asked whether this pathway had an in vivo role in mice. METHODS AND

resultsPerifemoral hematomas were used as a model of hematoma resolution. In mouse bone marrow-derived macrophages, heme induced HO-1, lipid regulatory genes including LXR (lipid X receptor), the growth factor IGF1 (insulin-like growth factor-1), and the splenic red pulp macrophage gene

conclusionsTaken together, these data demonstrate that both AMPK and ATF1 are required for normal hematoma resolution. Graphic Abstract: An online graphic abstract is available for this article.

Indexed as

Activating Transcription Factor 1AMP-Activated Protein KinasesAnimalsCells, CulturedDisease Models, AnimalDNA-Binding ProteinsErythrocytesFemaleHematomaHeme Oxygenase-1Insulin-Like Growth Factor IIronLipid MetabolismLiver X ReceptorsMacrophagesMaleActivating Transcription Factor 1AMP-Activated Protein KinasesAtf1 protein, mouseDNA-Binding ProteinsHeme Oxygenase-1Hmox1 protein, mouseinsulin-like growth factor-1, mouseInsulin-Like Growth Factor IIronLiver X ReceptorsMembrane ProteinsPrkab1 protein, mouseSpic protein, mousehemorrhageinflammationlipidsmacrophagesoxidative stress

Identifiers

PMID32611235
PMCPMC7478221
OpenAlexW3040398309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.