Evidence map›Paper›PMID 32611221›Full record

ArticleJournal of the American Heart Association2020

Seasonal Variations in the Pathogenesis of Acute Coronary Syndromes.

Osamu Kurihara, Masamichi Takano, Erika Yamamoto, Taishi Yonetsu, Tsunekazu Kakuta, Tsunenari Soeda, Bryan P Yan, Filippo Crea, Takumi Higuma, Shigeki Kimura and 13 more

Abstract readComparative StudyMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. The Japanese Society of Hypertension Practical Consensus Guidelines for Seasonal Blood Pressure Management.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  2. Article
  3. Seasonal patterns in diagnosis of coronary artery disease by CT-angiography-experience from a large real-world cohort.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Risk Factors Favoring Plaque Erosion.Current atherosclerosis reports · 2024
    Review
  12. Review
  13. Article
  14. Review
  15. Improved prehospital triage for acute cardiac care: results from HART-c, a multicentre prospective study.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2023
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Osamu KuriharaCardiology Division Massachusetts General Hospital Harvard Medical School Boston MA.
Masamichi TakanoCardiovascular Center Nippon Medical School Chiba Hokusoh Hospital Inzai, Chiba Japan.
Erika YamamotoCardiology Division Massachusetts General Hospital Harvard Medical School Boston MA.
Taishi YonetsuDepartment of Interventional Cardiology Tokyo Medical and Dental University Tokyo Japan.
Tsunekazu KakutaDivision of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Ibaraki Japan.
Tsunenari SoedaDepartment of Cardiovascular Medicine Nara Medical University Nara Japan.
Bryan P YanDivision of Cardiology Department of Medicine and Therapeutics Prince of Wales Hospital Chinese University of Hong Kong Hong Kong SAR China.
Filippo CreaFondazione Policlinico Universitario A Gemelli IRCCS Roma Italy.
Takumi HigumaDivision of Cardiology Department of Internal Medicine St. Marianna University School of Medicine Kawasaki Kanagawa Japan.
Shigeki KimuraDivision of Cardiology Kameda Medical Center Chiba Japan.
Yoshiyasu MinamiDepartment of Cardiovascular Medicine Kitasato University School of Medicine Sagamihara Japan.
Tom AdriaenssensDepartment of Cardiovascular Medicine University Hospitals Leuven Leuven Belgium.
Niklas F BoederDepartment of Cardiology University of Giessen Germany.
Holger M NefDepartment of Cardiology University of Giessen Germany.
Chong Jin KimDepartment of Cardiology Kyung Hee University Hospital Seoul Korea.
Vikas ThondapuCardiology Division Massachusetts General Hospital Harvard Medical School Boston MA.
Hyung Oh KimCardiology Division Massachusetts General Hospital Harvard Medical School Boston MA.
Michele RussoCardiology Division Massachusetts General Hospital Harvard Medical School Boston MA.
Tomoyo SugiyamaCardiology Division Massachusetts General Hospital Harvard Medical School Boston MA.
Francesco FracassiCardiology Division Massachusetts General Hospital Harvard Medical School Boston MA.
Hang LeeBiostatistics Center Massachusetts General Hospital Harvard Medical School Boston MA.
Kyoichi MizunoMitsukoshi Health and Welfare Foundation Tokyo Japan.
Ik-Kyung JangCardiology Division Massachusetts General Hospital Harvard Medical School Boston MA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Seasonal variations in acute coronary syndromes (ACS) have been reported, with incidence and mortality peaking in the winter. However, the underlying pathophysiology for these variations remain speculative. Methods and Results Patients with ACS who underwent optical coherence tomography were recruited from 6 countries. The prevalence of the 3 most common pathologies (plaque rupture, plaque erosion, and calcified plaque) were compared between the 4 seasons. In 1113 patients with ACS (885 male; mean age, 65.8±11.6 years), the rates of plaque rupture, plaque erosion, and calcified plaque were 50%, 39%, and 11% in spring; 44%, 43%, and 13% in summer; 49%, 39%, and 12% in autumn; and 57%, 30%, and 13% in winter (

Indexed as

SeasonsAcute Coronary SyndromeAgedCoronary Artery DiseaseEuropeFemaleHeart Disease Risk FactorsHumansIncidenceJapanMaleMiddle AgedPlaque, AtheroscleroticPrevalenceRegistriesRupture, Spontaneousoptical coherence tomographyplaque erosionplaque ruptureseason

Identifiers

PMID32611221
PMCPMC7670515

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.