Evidence map›Paper›PMID 32611198›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2020

The M1 muscarinic acetylcholine receptor in the crypt stem cell compartment mediates intestinal mucosal growth.

Chasen J Greig, Sarah J Armenia, Robert A Cowles

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Ghrelin Induces CluInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Article
  4. The enteric nervous system.Physiological reviews · 2023
    Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Chasen J GreigDepartment of Surgery, Yale School of Medicine, New Haven, CT 06510, USA.
Sarah J ArmeniaDepartment of Surgery, Yale School of Medicine, New Haven, CT 06510, USA.
Robert A CowlesDepartment of Surgery, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-3375-9158
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

impact statementLocalization of a specific subtype of the muscarinic acetylcholine receptor in the crypt stem cell compartment suggests a critical role in intestinal mucosal homeostasis. Here we demonstrate the localization of the M1 muscarinic acetylcholine receptor to the stem cell compartment and demonstrate increase morphometric and proliferative parameters when this is stimulated

Indexed as

AcetylcholineAnimalsCell ProliferationHomeostasisIntestinal MucosaJejunumMaleMiceMice, Inbred C57BLReceptor, Muscarinic M1Receptors, CholinergicReceptors, G-Protein-CoupledRNA, MessengerSignal TransductionStem CellsAcetylcholineReceptor, Muscarinic M1Receptors, CholinergicReceptors, G-Protein-CoupledRNA, Messengerintestinal cryptsintestinal homeostasisintestinal stem cellsmouse modelmucosal growthMuscarinic acetylcholine receptors

Identifiers

PMID32611198
PMCPMC7437377
OpenAlexW3039660569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.