ReviewJournal of clinical medicine2020
Bioactive Surfaces vs. Conventional Surfaces in Titanium Dental Implants: A Comparative Systematic Review.
Review in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Bridging the missing middle in osseointegration: meso-scale topography between macro design and microroughness.International journal of implant dentistry · 2025Pooled it
- Do Super-hydrophilic Surfaces Affect Implant Primary Stability in the Early Healing Phase of Osseointegration? A Systematic Review with Metanalysis.Oral health & preventive dentistry · 2025Pooled it
- Biomimetic Surface Engineering Strategies for Enhanced Osseointegration and Peri-Implant Bone Regeneration: A Systematic Review.Biomimetics (Basel, Switzerland) · 2026Review
- Multiscale Interface Engineering for Orthopedic and Dental Implants: A Review.Journal of functional biomaterials · 2026Review
- Influence of the Topography of Zirconium Treated with Laser Micropatterning on Periodontal Ligament Stem Cells: An In Vitro Study.Journal of functional biomaterials · 2026Article
- Enhancing Titanium Surface Properties with Castor Oil-Based Polyurethane: A Sustainable and Low-Cytotoxicity Approach.ACS omega · 2025Article
- The 3D theory of osseointegration: material, topography, and time as interdependent determinants of bone-implant integration.International journal of implant dentistry · 2025Review
- Controlling Sodium Titanate Crystal Size to Improve Wettability and Early Osseointegration of Titanium Implants: Insights from an Animal Model.Journal of functional biomaterials · 2025Article
- Functional Assessment of Microplasma-Sprayed Hydroxyapatite-Zirconium Bilayer Coatings: Mechanical and Biological Perspectives.Materials (Basel, Switzerland) · 2025Article
- Comparative Study of Acid Etching and SLA Surface Modification for Titanium Implants.Materials (Basel, Switzerland) · 2025Article
- Advanced Strategies for Enhancing the Biocompatibility and Antibacterial Properties of Implantable Structures.Materials (Basel, Switzerland) · 2025Review
- Significant Interaction between Melatonin and Titanium Bone Implants: Available Evidence and Future Research Directions.Current pharmaceutical biotechnology · 2025Review
- Review
- Exploring the Broad Spectrum of Titanium-Niobium Implants and Hydroxyapatite Coatings-A Review.Materials (Basel, Switzerland) · 2024Review
- Randomized Clinical Trial: Bone Bioactive Liquid Improves Implant Stability and Osseointegration.Journal of functional biomaterials · 2024Article
- Beyond microroughness: novel approaches to navigate osteoblast activity on implant surfaces.International journal of implant dentistry · 2024Review
- Biomimetic Coatings in Implant Dentistry: A Quick Update.Journal of functional biomaterials · 2023Review
- Influence of Topography and Composition of Commercial Titanium Dental Implants on Cell Adhesion of Human Gingiva-Derived Mesenchymal Stem Cells: An In Vitro Study.International journal of molecular sciences · 2023Article
- A Bioinspired Gelatin-Amorphous Calcium Phosphate Coating on Titanium Implant for Bone Regeneration.Advanced healthcare materials · 2023Article
- Employing Indirect Adenosine 2Journal of functional biomaterials · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animal studies and the scarce clinical trials available that have been conducted suggest that bioactive surfaces on dental implants could improve the osseointegration of such implants. The purpose of this systematic review was to compare the effectiveness of osseointegration of titanium (Ti) dental implants using bioactive surfaces with that of Ti implants using conventional surfaces such as sandblasted large-grit acid-etched (SLA) or similar surfaces. Applying the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement, the MEDLINE, PubMed Central and Web of Science databases were searched for scientific articles in April 2020. The keywords used were "dental implants", "bioactive surfaces", "biofunctionalized surfaces", and "osseointegration", according to the question: "Do bioactive dental implant surfaces have greater osseointegration capacity compared with conventional implant surfaces?" Risk of bias was assessed using the Cochrane Collaboration tool. 128 studies were identified, of which only 30 met the inclusion criteria: 3 clinical trials and 27 animal studies. The average STROBE (STrengthening the Reporting of OBservational studies in Epidemiology) and ARRIVE (Animal Research: Reporting of In Vivo Experiments) scores were 15.13 ± 2.08 and 17.7±1.4, respectively. Implant stability quotient (ISQ) was reported in 3 studies; removal torque test (RTT)-in 1 study; intraoral periapical X-ray and microcomputed tomography radiological evaluation (RE)-in 4 studies; shear force (SF)-in 1 study; bone-to-implant contact (BIC)-in 12 studies; and BIC and bone area (BA) jointly-in 5 studies. All animal studies reported better bone-to-implant contact surface for bioactive surfaces as compared to control implants with a statistical significance of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.