Evidence map›Paper›PMID 32610587›Full record

ArticleJournal of clinical medicine2020

Does SARS-CoV-2 Trigger Stress-InducedAutoimmunity by Molecular Mimicry? A Hypothesis.

Francesco Cappello, Antonella Marino Gammazza, Francesco Dieli, de Macario, Alberto Jl Macario

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

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  6. Case report of secondary T-cell deficiency following the AstraZeneca COVID-19 vaccine.The journal of allergy and clinical immunology. Global · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Francesco CappelloDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo,90127 Palermo, Italy.
Antonella Marino GammazzaDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo,90127 Palermo, Italy.
Francesco DieliDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo,90127 Palermo, Italy.
de MacarioEuro-Mediterranean Institute of Science and Technology (IEMEST), 90141 Palermo, Italy.
Alberto Jl MacarioEuro-Mediterranean Institute of Science and Technology (IEMEST), 90141 Palermo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viruses can generate molecular mimicry phenomena within their hosts. Why shouldsevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) not be considered one of these?Information in this short review suggests that it might be so and, thus, encourages research aimingat testing this possibility. We propose, as a working hypothesis, that the virus induces antibodiesand that some of them crossreact with host's antigens, thus eliciting autoimmune phenomena withdevasting consequences in various tissues and organs. If confirmed, by in vitro and in vivo tests,this could drive researchers to find effective treatments against the virus.

Indexed as

antistress proteinscell stressCOVID-19crossreactive antibodiesmolecular chaperonesmolecular mimicrySARS-CoV-2

Identifiers

PMID32610587
PMCPMC7408943

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.