Evidence map›Paper›PMID 32610581›Full record

ArticleCancers2020

Pimasertib Versus Dacarbazine in Patients With Unresectable

Celeste Lebbé, Caroline Dutriaux, Thierry Lesimple, Willem Kruit, Joseph Kerger, Luc Thomas, Bernard Guillot, Filippo de Braud, Claus Garbe, Jean-Jacques Grob and 10 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Quality-of-life measures in pharmacogenomic studies: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Pathology and Molecular Biology of Melanoma.Current issues in molecular biology · 2023
    Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 18 institutions in 10 countries.

Celeste LebbéAP-HP Dermatology CIC Department, Saint Louis Hospital, and INSERM U976, Université de Paris, 75010 Paris, France.
Caroline DutriauxDermatology, Hopital Saint-Andre-CHU, 33000 Bordeaux, France.
Thierry LesimpleMedical Oncology Department, Comprehensive Cancer Center Eugène Marquis, 35000 Rennes, France.
Willem KruitInternal Oncology, Erasmus MC Cancer Institute, 3008 AE Rotterdam, The Netherlands.
Joseph KergerMedical Oncology, Institut Jules Bordet, 1000 Brussels, Belgium.
Luc ThomasDepartment of Dermatology, Centre Hospitalier Lyon Sud, 69310 Pierre Bénite, France.
Bernard GuillotDepartment of Dermatology, Hôpital Saint Eloi, 34295 Montpellier, France.
Filippo de BraudDepartment of Medical Oncology, Istituto Nazionale dei Tumori, Università degli Studi di Milano, 20133 Milano, Italy.
Claus GarbeDepartment of Dermatology, University Hospital Tübingen, 72076 Tübingen, Germany.
Jean-Jacques GrobDepartment of Dermatology and Cutaneous Oncology Service, Hôpital de la Timone, 13005 Marseille, France.
Carmen LoquaiDepartment of Dermatology, University Medical Center Mainz, 55019 Mainz, Germany.
Virginia FerraresiDivision of Medical Oncology 1, IRCCS "Regina Elena" National Cancer Institute, 00144 Roma, Italy.
Caroline RobertDermatology Department, Institut Gustave Roussy and Paris Sud University, 94800 Villejuif, France.
Paul VaseyIcon Cancer Care, The Wesley Hospital, Auchenflower, QLD 4066, Australia.
Robert ConryComprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Richard IsaacsMidCentral Regional Cancer Treatment Service, Palmerston North Hospital, Palmerston North 4442, New Zealand.
Enrique EspinosaMedical Oncology Department, Hospital Universitario La Paz, 28046 Madrid, Spain.
Armin SchuelerGlobal Biostatistics Oncology, Merck KGaA, 64293 Darmstadt, Germany.ORCID 0000-0003-3833-5757
Giorgio MassiminiGCDU Oncology, Merck KGaA, 64293 Darmstadt, Germany.
Brigitte DrénoDepartment of Dermato Cancerology, CIC 1413, CRCINA Inserm 1232, CHU Nantes, 44093 Nantes, France.
Inserm · FRMerck (Germany) · DECentre Eugène Marquis · FRErasmus MC · NLHôpital de la Timone · FRHôpital Saint-André · FRHôpital Saint Eloi · FRHospices Civils de Lyon · FRHospital Universitario La Paz · ESInstitut Jules Bordet · BEJohannes Gutenberg University Mainz · DEPalmerston North Hospital · NZTumori Foundation · USUniversitätsklinikum Tübingen · DEUniversité Paris-Sud · FRUniversity of Alabama at Birmingham · USUniversity of Milan · ITWesley Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the efficacy and safety of pimasertib (

Indexed as

adverse eventsdacarbazinemalignant melanomaN-(2,3-dihydroxypropyl)-1-((2-fluoro-4-iodophenyl)amino)isonicotinamidepimasertibprogression-free survivalquality of life

Identifiers

PMID32610581
PMCPMC7408351
OpenAlexW3037332115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.