Evidence map›Paper›PMID 32610530›Full record

ArticleInternational journal of molecular sciences2020

Special Issue on "The Tight Junction and Its Proteins: More than Just a Barrier".

Susanne M Krug, Michael Fromm

Abstract readEditorial
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Frontiers in pharmacology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Gut barrier protein levels in serial blood samples from critically ill trauma patients during and after intensive care unit stay.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023
    Article
  12. Review
  13. Review
  14. Article
  15. The Fate of Epidermal Tight Junctions in theInternational journal of molecular sciences · 2022
    Article
  16. Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Susanne M KrugInstitute of Clinical Physiology/Nutritional Medicine, Department of Gastroenterology, Rheumatology and Infectious Diseases, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, 12203 Berlin, Germany.ORCID 0000-0002-1293-2484
Michael FrommInstitute of Clinical Physiology/Nutritional Medicine, Department of Gastroenterology, Rheumatology and Infectious Diseases, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, 12203 Berlin, Germany.ORCID 0000-0003-4497-7983

Funding

Deutsche Forschungsgemeinschaft GRK 2318, A3 and C2Deutsche Forschungsgemeinschaft TRR 241, B06
6 · The paper itself

Abstract

For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ-mainly, the two families of claudins and TAMPs-several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue covers numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, the function of and regulation by proteins of the tricellular TJ, the TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJs as sensors and reactors to environmental conditions, and last, but not least, TJ proteins and cancer. It is not surprising that due to this diversity of topics and functions, the still-young field of TJ research is growing fast. This Editorial gives an introduction to all 43 papers of the Special Issue in a structured topical order.

Indexed as

AnimalsClaudinsHumansOccludinTight Junction ProteinsTight JunctionsClaudinsOccludinTight Junction Proteinsangulincancercell polarityclaudinenvironmental sensorsimmune cellsoccludinparacellular channels and barrierspathogenstight junctiontricellulin

Identifiers

PMID32610530
PMCPMC7370070

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.