Evidence map›Paper›PMID 32610475›Full record

ArticleGenes2020

Cardiac Transcriptome Analysis Reveals Nr4a1 Mediated Glucose Metabolism Dysregulation in Response to High-Fat Diet.

Lihui Men, Wenting Hui, Xin Guan, Tongtong Song, Xuan Wang, Siwei Zhang, Xia Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lihui MenDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Wenting HuiDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Xin GuanDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Tongtong SongDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Xuan WangDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Siwei ZhangDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Xia ChenDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is associated with an increased risk of developing cardiovascular disease (CVD), with limited alterations in cardiac genomic characteristics known. Cardiac transcriptome analysis was conducted to profile gene signatures in high-fat diet (HFD)-induced obese mice. A total of 184 differentially expressed genes (DEGs) were identified between groups. Based on the gene ontology (GO) term enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of DEGs, the critical role of closely interlocked glucose metabolism was determined in HFD-induced cardiac remodeling DEGs, including

Indexed as

TranscriptomeAnimalsCell LineDiet, High-FatFibroblast Growth FactorsGlucoseGlucose Transporter Type 3Hydroxymethylglutaryl-CoA SynthaseIntracellular Signaling Peptides and ProteinsMaleMiceMice, Inbred C57BLMyocardiumNuclear Receptor Subfamily 4, Group A, Member 1ObesityPhosphoenolpyruvate Carboxykinase (GTP)fibroblast growth factor 21Fibroblast Growth FactorsGlucoseGlucose Transporter Type 3HMGCS2 protein, mouseHydroxymethylglutaryl-CoA SynthaseIntracellular Signaling Peptides and ProteinsNr4a1 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 1Pck1 protein, mousePhosphoenolpyruvate Carboxykinase (GTP)Slc2a3 protein, mousecardiac transcriptome analysisglucose metabolismhigh-fat dietNr4a1

Identifiers

PMID32610475
PMCPMC7397175
OpenAlexW3037257048

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.