Evidence map›Paper›PMID 32610344›Full record

ArticleNature2020

Structural basis of CXC chemokine receptor 2 activation and signalling.

Kaiwen Liu, Lijie Wu, Shuguang Yuan, Meng Wu, Yueming Xu, Qianqian Sun, Shu Li, Suwen Zhao, Tian Hua, Zhi-Jie Liu

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 1 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 1 synthesis or guideline pooled it, 232 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Interleukin-8 in health and disease.Molecular biomedicine · 2026
    Review
  6. Article
  7. Structure basis for C-C chemokine receptor 4 modulation by orthosteric and allosteric antagonists.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Intracellular and dual-site inhibition of a bitter taste GPCR.Cellular and molecular life sciences : CMLS · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Roles of chemokines in pancreatitis: A review.World journal of gastrointestinal pathophysiology · 2025
    Review
  17. Multiscale Computational Dissection of CCRL2-Mediated Chemerin Presentation.Journal of chemical information and modeling · 2025
    Article
  18. Article
  19. Review
  20. Article

80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Kaiwen LiuiHuman Institute, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0000-0002-2186-8031
Lijie WuiHuman Institute, ShanghaiTech University, Shanghai, China.
Shuguang YuanThe Research Center for Computer-aided Drug Discovery, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Meng WuiHuman Institute, ShanghaiTech University, Shanghai, China.
Yueming XuiHuman Institute, ShanghaiTech University, Shanghai, China.
Qianqian SuniHuman Institute, ShanghaiTech University, Shanghai, China.
Shu LiThe Research Center for Computer-aided Drug Discovery, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Suwen ZhaoiHuman Institute, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0000-0001-5609-434X
Tian HuaiHuman Institute, ShanghaiTech University, Shanghai, China. huatian@shanghaitech.edu.cn.ORCID http://orcid.org/0000-0002-6132-2068
Zhi-Jie LiuiHuman Institute, ShanghaiTech University, Shanghai, China. liuzhj@shanghaitech.edu.cn.ORCID http://orcid.org/0000-0001-7279-2893
ShanghaiTech University · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemokines and their receptors mediate cell migration, which influences multiple fundamental biological processes and disease conditions such as inflammation and cancer

Indexed as

Models, MolecularSignal TransductionAllosteric RegulationAllosteric SiteChemokinesGTP-Binding Protein alpha Subunits, Gi-GoHumansInterleukin-8Protein BindingReceptors, Interleukin-8BStructure-Activity RelationshipSubstrate SpecificityChemokinesCXCL8 protein, humanCXCR2 protein, humanGTP-Binding Protein alpha Subunits, Gi-GoInterleukin-8Receptors, Interleukin-8B

Identifiers

PMID32610344
OpenAlexW3038311311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.