Evidence map›Paper›PMID 32610113›Full record

ReviewMolecular and cellular endocrinology2020

Updates on molecular and environmental determinants of luteal progesterone production.

Natalie A DeWitt, Shannon Whirledge, Amanda N Kallen

Open access · greenAbstract readReview
In one paragraph

Review in Molecular and cellular endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Veterinary sciences · 2022
    Article
  7. Evaluation of Triclosan Effects on Cultured Swine Luteal Cells.Animals : an open access journal from MDPI · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Natalie A DeWittDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.
Shannon WhirledgeDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.
Amanda N KallenDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA. Electronic address: Amanda.kallen@yale.edu.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
REPRODUCTIVE SCIENTIST TRAINING PROGRAMK12HD000849 · NICHD · WASHINGTON UNIVERSITY · PI Danny J Schust · 1988 to 2026
$33.2M
The Regulation of Ovarian Aging by H19 and let-7R01HD101475 · NICHD · YALE UNIVERSITY · PI KALLEN, AMANDA NICOLE · 2020 to 2024
$1.8M
Environmental Exposure to Genistein Regulates Signal Transduction in the UterusR00ES022983 · NIEHS · YALE UNIVERSITY · PI WHIRLEDGE, SHANNON D · 2016 to 2018
$736k
NCATS NIH HHS UL1 TR001863NICHD NIH HHS K12 HD000849NICHD NIH HHS L50 HD081739NICHD NIH HHS R01 HD101475NIEHS NIH HHS R00 ES022983
6 · The paper itself

Abstract

Progesterone, a critical hormone in reproduction, is a key sex steroid in the establishment and maintenance of early pregnancy and serves as an intermediary for synthesis of other steroid hormones. Progesterone production from the corpus luteum is a tightly regulated process which is stimulated and maintained by multiple factors, both systemic and local. Multiple regulatory systems, including classic mediators of gonadotropin stimulation such as the cAMP/PKA pathway and TGFβ-mediated signaling pathways, as well as local production of hormonal factors, exist to promote granulosa cell function and physiological fine-tuning of progesterone levels. In this manuscript, we provide an updated narrative review of the known mediators of human luteal progesterone and highlight new observations regarding this important process, focusing on studies published within the last five years. We will also review recent evidence suggesting that this complex system of progesterone production is sensitive to disruption by exogenous environmental chemicals that can mimic or interfere with the activities of endogenous hormones.

Indexed as

AnimalsChorionic GonadotropinCorpus LuteumFemaleGranulosa CellsHumansProgesteroneChorionic GonadotropinProgesteroneCorpus luteumEndocrine disrupting chemicalsGranulosa cellProgesteroneSteroidogenesis

Identifiers

PMID32610113
PMCPMC7484338
OpenAlexW3037948826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.