Evidence map›Paper›PMID 32609829›Full record

ArticleThe Journal of clinical endocrinology and metabolism2020

Glucocorticoid Excess in Patients with Pheochromocytoma Compared with Paraganglioma and Other Forms of Hypertension.

Georgiana Constantinescu, Katharina Langton, Catleen Conrad, Laurence Amar, Guillaume Assié, Anne-Paule Gimenez-Roqueplo, Anne Blanchard, Casper K Larsen, Paolo Mulatero, Tracy Ann Williams and 14 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

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  15. Observational
  16. Article
  17. Adrenal Hormone Interactions and Metabolism: A Single Sample Multi-Omics Approach.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2021
    Article
  18. Article
  19. Best Achievements in Pituitary and Adrenal Diseases in 2020.Endocrinology and metabolism (Seoul, Korea) · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 14 institutions in 10 countries.

Georgiana ConstantinescuDepartment of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Katharina LangtonInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Catleen ConradInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Laurence AmarHôpital Européen Georges Pompidou, Hypertension Unit, APHP, Paris, France.
Guillaume AssiéParis Descartes University, Sorbonne Paris Cité, Paris, France.
Anne-Paule Gimenez-RoqueploCardiovascular Research Center INSERM, Paris, France.
Anne BlanchardParis Descartes University, Sorbonne Paris Cité, Paris, France.
Casper K LarsenCardiovascular Research Center INSERM, Paris, France.
Paolo MulateroDivision of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Italy.
Tracy Ann WilliamsDivision of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Italy.
Aleksander PrejbiszDepartment of Hypertension, Institute of Cardiology, Warsaw, Poland.
Martin FassnachtDepartment of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of Würzburg, Würzburg, Germany.
Stefan BornsteinDepartment of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Filippo CeccatoEndocrinology Unit, Department of Medicine DIMED, Padova University Hospital, Padua, Italy.
Stephanie FliednerFirst Department of Medicine, University Medical Center Schleswig-Holstein, Lübeck, Germany.
Michael DennedyThe Discipline of Pharmacology and Therapeutics, School of Medicine, National University of Ireland Galway, Galway, Ireland.
Mirko PeitzschInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Richard SinnottSchool of Computing and Information Systems, University of Melbourne, Melbourne, Australia.
Andrzej JanuszewiczDepartment of Hypertension, Institute of Cardiology, Warsaw, Poland.
Felix BeuschleinMedizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany.
Martin ReinckeMedizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany.
Maria-Christina ZennaroCardiovascular Research Center INSERM, Paris, France.
Graeme EisenhoferDepartment of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Jaap DeinumDepartment of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Délégation Paris 5 · FRUniversity Hospital Carl Gustav Carus · DELMU Klinikum · DEInserm · FRInstitute of Cardiology · PLGrigore T. Popa University of Medicine and Pharmacy · ROKing's College London · GBOllscoil na Gaillimhe – University of Galway · IERadboud University Nijmegen · NLThe University of Melbourne · AUUniversity Hospital Schleswig-Holstein · DEUniversity of Padua · ITUniversity of Turin · ITUniversity of Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextCatecholamines and adrenocortical steroids are important regulators of blood pressure. Bidirectional relationships between adrenal steroids and catecholamines have been established but whether this is relevant to patients with pheochromocytoma is unclear.

objectiveThis study addresses the hypothesis that patients with pheochromocytoma and paraganglioma (PPGL) have altered steroid production compared with patients with primary hypertension.

designMulticenter cross-sectional study.

settingTwelve European referral centers. PATIENTS: Subjects included 182 patients with pheochromocytoma, 36 with paraganglioma and 270 patients with primary hypertension. Patients with primary aldosteronism (n = 461) and Cushing syndrome (n = 124) were included for additional comparisons.

interventionIn patients with PPGLs, surgical resection of tumors. OUTCOME MEASURES: Differences in mass spectrometry-based profiles of 15 adrenal steroids between groups and after surgical resection of PPGLs. Relationships of steroids to plasma and urinary metanephrines and urinary catecholamines.

resultsPatients with pheochromocytoma had higher (P < .05) circulating concentrations of cortisol, 11-deoxycortisol, 11-deoxycorticosterone, and corticosterone than patients with primary hypertension. Concentrations of cortisol, 11-deoxycortisol, and corticosterone were also higher (P < .05) in patients with pheochromocytoma than with paraganglioma. These steroids correlated positively with plasma and urinary metanephrines and catecholamines in patients with pheochromocytoma, but not paraganglioma. After adrenalectomy, there were significant decreases in cortisol, 11-deoxycortisol, corticosterone, 11-deoxycorticosterone, aldosterone, and 18-oxocortisol.

conclusionsThis is the first large study in patients with PPGLs that supports in a clinical setting the concept of adrenal cortical-medullary interactions involving an influence of catecholamines on adrenal steroids. These findings could have implications for the cardiovascular complications of PPGLs and the clinical management of patients with the tumors.

Indexed as

Adrenal Gland NeoplasmsAdultAgedCross-Sectional StudiesEuropeFemaleGlucocorticoidsHumansHyperaldosteronismHypertensionMaleMiddle AgedParagangliomaPheochromocytomaRetrospective StudiesGlucocorticoidshypertensionmetanephrinesparagangliomapheochromocytomasteroids

Identifiers

PMID32609829
PMCPMC7413598
OpenAlexW3040125116

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.