ArticleChemical senses2020
Olfactory Detection Thresholds for Primary Aliphatic Alcohols in Mice.
Article in Chemical senses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
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- Gustatory and olfactory-guided responsiveness to maltodextrin solutions in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Constructing an Olfactometer for Rodent Olfactory Behavior Studies.Journal of visualized experiments : JoVE · 2025Article
- Recalibrating Olfactory Neuroscience to the Range of Naturally Occurring Odor Concentrations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Recent odor experience selectively modulates olfactory sensitivity across the glomerular output in the mouse olfactory bulb.Chemical senses · 2025Article
- Direct Piriform-to-Auditory Cortical Projections Shape Auditory-Olfactory Integration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Recent odor experience selectively modulates olfactory sensitivity across the glomerular output in the mouse olfactory bulb.bioRxiv : the preprint server for biology · 2024Article
- Direct piriform-to-auditory cortical projections shape auditory-olfactory integration.bioRxiv : the preprint server for biology · 2024Article
- The behavioral sensitivity of mice to acyclic, monocyclic, and bicyclic monoterpenes.PloS one · 2024Article
- Vasopressin receptor 1a, oxytocin receptor, and oxytocin knockout male and female mice display normal perceptual abilities towards non-social odorants.Hormones and behavior · 2023Article
- Estimating the relationship between liquid- and vapor-phase odorant concentrations using a photoionization detector (PID)-based approach.Chemical senses · 2023Article
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- The behavioral sensitivity of mice to acetate esters.Chemical senses · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Probing the neural mechanisms that underlie each sensory system requires the presentation of perceptually appropriate stimulus concentrations. This is particularly relevant in the olfactory system as additional odorant receptors typically respond with increasing stimulus concentrations. Thus, perceptual measures of olfactory sensitivity provide an important guide for functional experiments. This study focuses on aliphatic alcohols because they are commonly used to survey neural activity in a variety of olfactory regions, probe the behavioral limits of odor discrimination, and assess odor-structure activity relationships in mice. However, despite their frequent use, a systematic study of the relative sensitivity of these odorants in mice is not available. Thus, we assayed the ability of C57BL/6J mice to detect a homologous series of primary aliphatic alcohols (1-propanol to 1-heptanol) using a head-fixed Go/No-Go operant conditioning assay combined with highly reproducible stimulus delivery. To aid in the accessibility of our data, we report the animal's threshold to each odorant according to the 1) ideal gas condition, 2) nonideal gas condition (factoring in the activity of the odorant in the solvent), and 3) the liquid dilution of the odorant in the olfactometer. Of the odorants tested, mice were most sensitive to 1-hexanol and least sensitive to 1-butanol. These updated measures of murine sensitivity will hopefully guide experimenters in choosing appropriate stimulus concentrations for experiments using these odorants.
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