ArticlePLoS genetics2020
Brassinosteroids regulate root meristem development by mediating BIN2-UPB1 module in Arabidopsis.
Article in PLoS genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 65 citations in OpenAlex.
- A BIN2-SOG1 molecular module regulates replication stress response independently on ATR.Science advances · 2026Article
- Mapping the Phosphorylation Regulatory Network of Single-Celled Fibre Elongation Mediated by GhBIN2 in Cotton.Plant biotechnology journal · 2025Article
- Plant Signaling Hormones and Transcription Factors: Key Regulators of Plant Responses to Growth, Development, and Stress.Plants (Basel, Switzerland) · 2025Review
- Crosstalk among plant hormone regulates the root development.Plant signaling & behavior · 2024Review
- Research on the Mechanisms of Phytohormone Signaling in Regulating Root Development.Plants (Basel, Switzerland) · 2024Review
- Arabidopsis proteinProceedings of the National Academy of Sciences of the United States of America · 2024Article
- BZR1 and BES1 transcription factors mediate brassinosteroid control over root system architecture in response to nitrogen availability.Frontiers in plant science · 2024Article
- Characterization of Almond Scion/Rootstock Communication in Cultivar and Rootstock Tissues through an RNA-Seq Approach.Plants (Basel, Switzerland) · 2023Article
- Article
- StBIN2 Positively Regulates Potato Formation through Hormone and Sugar Signaling.International journal of molecular sciences · 2023Article
- Chloroplast metalloproteinase SlL2 reduces the thermotolerance of tomato by decreasing the content of SlCDJ1.Protoplasma · 2023Article
- MERISTEM-DEFECTIVE regulates the balance between stemness and differentiation in the root meristem through RNA splicing control.Development (Cambridge, England) · 2023Article
- Regulatory network of GSK3-like kinases and their role in plant stress response.Frontiers in plant science · 2023Review
- BIN2 phosphorylates the Thr280 of CO to restrict its function in promotingFrontiers in plant science · 2023Article
- CcRR5 interacts with CcRR14 and CcSnRK2s to regulate the root development in citrus.Frontiers in plant science · 2023Article
- Integration of multi-omics data reveals interplay between brassinosteroid and Target of Rapamycin Complex signaling in Arabidopsis.The New phytologist · 2022Article
- Salicylic acid-activated BIN2 phosphorylation of TGA3 promotes Arabidopsis PR gene expression and disease resistance.The EMBO journal · 2022Article
- Brassinosteroid signaling restricts root lignification by antagonizing SHORT-ROOT function in Arabidopsis.Plant physiology · 2022Article
- Genome-wide identification and expression analysis of the GSK gene family in wheat (Triticum aestivum L.).Molecular biology reports · 2022Article
- Metabolomics Mechanism and Lignin Response to Laxogenin C, a Natural Regulator of Plants Growth.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant steroid hormones brassinosteroids (BRs) regulate plant growth and development at many levels. While negative regulatory factors that inhibit development and are counteracted by BRs exist in the root meristem, these factors have not been characterized. The functions of UPB1 transcription factor in BR-regulated root growth have not been established, although its role in regulating root are well documented. Here, we found that BIN2 interacts with and phosphorylates the UPB1 transcription factor consequently promoting UPB1 stability and transcriptional activity. Genetic analysis revealed that UPB1 deficiency could partially recover the short-root phenotype of BR-deficient mutants. Expression of a mutated UPB1S37AS41A protein lacking a conserved BIN2 phosphorylation sites can rescue shorter root phenotype of bin2-1 mutant. In addition, UPB1 was repressed by BES1 at the transcriptional level. The paclobutrazol-resistant protein family (PRE2/3) interacts with UPB1 and inhibits its transcriptional activity to promote root meristem development, and BIN2-mediated phosphorylation of UPB1 suppresses its interaction with PRE2/3, and subsequently impairing root meristem development. Taken together, our data elucidate a molecular mechanism by which BR promotes root growth via inhibiting BIN2-UPB1 module.
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