Evidence map›Paper›PMID 32609390›Full record

ReviewJournal of medical virology2021

Discharged COVID-19 patients testing positive again for SARS-CoV-2 RNA: A minireview of published studies from China.

Zhiyong Han, Fortunato Battaglia, Stanley R Terlecky

Abstract readReview
In one paragraph

Review in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Is recurrence possible in coronavirus disease 2019 (COVID-19)? Case series and systematic review of literature.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Role of melatonin in respiratory diseases (Review).Experimental and therapeutic medicine · 2022
    Review
  8. Article
  9. Development of a rapid point-of-care test that measures neutralizing antibodies to SARS-CoV-2.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zhiyong HanDepartment of Medical Sciences, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey.ORCID 0000-0001-7732-7368
Fortunato BattagliaDepartment of Medical Sciences, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey.
Stanley R TerleckyDepartment of Medical Sciences, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the ongoing coronavirus disease 2019 (COVID-19) pandemic, one potential cause of concern is that some discharged COVID-19 patients are testing positive again for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA. To better understand what is happening and to provide public health policy planners and clinicians timely information, we have searched and reviewed published studies about discharged patients testing positive again for the SARS-CoV-2 RNA. Our search found 12 reports, all of which described patients in China. Our review of these reports indicates the presence of discharged patients who remain asymptomatic but test positive. However, it is unclear whether they are contagious because a positive reverse transcriptase - polymerase chain reaction (RT- PCR) test does not necessarily indicate the presence of replicating and transmissible virus. Our review suggests the need for timely, parallel testing of different samples, including, for example, fecal specimens, from COVID-19 patients before and after they are discharged from hospitals.

Indexed as

Asymptomatic InfectionsChinaCOVID-19COVID-19 Nucleic Acid TestingFalse Negative ReactionsHumansPatient DischargeReverse Transcriptase Polymerase Chain ReactionRNA, ViralSARS-CoV-2RNA, Viralcoronavirusinfectionpathogenesisreactivationrespiratory tractsheddingvirus classification

Identifiers

PMID32609390
PMCPMC7361580

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.