Evidence map›Paper›PMID 32608995›Full record

ArticleCell transplantation

Intra-articular Injection of Cell-laden 3D Microcryogels Empower Low-dose Cell Therapy for Osteoarthritis in a Rat Model.

Dan Xing, Wei Liu, Bin Wang, Jiao Jiao Li, Yu Zhao, Hui Li, Aifeng Liu, Yanan Du, Jianhao Lin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Minimally Invasive Therapies for Knee Osteoarthritis.Journal of personalized medicine · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Injectable amnion hydrogel-mediated delivery of adipose-derived stem cells for osteoarthritis treatment.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Dan XingArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, China.
Wei LiuDepartment of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, Beijing, China.
Bin WangDepartment of Orthopaedics, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Jiao Jiao LiKolling Institute, University of Sydney, Sydney, NSW, Australia.
Yu ZhaoArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, China.
Hui LiArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, China.
Aifeng LiuDepartment of Orthopedics, The First affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Yanan DuDepartment of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, Beijing, China.
Jianhao LinArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, China.ORCID 0000-0003-1830-9244
Peking University · CNCenter for Life Sciences · CNShanxi Medical University · CNThe University of Sydney · AUTianjin University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intra-articular injection of mesenchymal stem cells (MSCs) in an osteoarthritic joint can help slow down cartilage destruction. However, cell survival and the efficiency of repair are generally low due to mechanical damage during injection and a high rate of cell loss. We, thus, investigated an improved strategy for cell delivery to an osteoarthritic joint through the use of three-dimensional (3D) microcryogels. MSCs were seeded into 3D microcryogels. The viability and proliferation of MSCs in microcryogels were determined over 5 d, and the phenotype of MSCs was confirmed through trilineage differentiation tests and flow cytometry. In Sprague Dawley rats with induced osteoarthritis (OA) of the knee joint, a single injection was made with the following groups: saline control, low-dose free MSCs (1 × 10

Indexed as

AnimalsCell- and Tissue-Based TherapyDisease Models, AnimalImaging, Three-DimensionalInjections, Intra-ArticularOsteoarthritisRatsRats, Sprague-Dawleycartilage repairhydrogelsmesenchymal stem cellsmicrocryogelsosteoarthritis

Identifiers

PMID32608995
PMCPMC7563831
OpenAlexW3038804161

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.