ArticleJournal of biomedical materials research. Part A2021
Acid bone lysates reduce bone regeneration in rat calvaria defects.
Article in Journal of biomedical materials research. Part A, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Pulsed Nd:YAG laser therapy accelerates fracture healing in a rat femoral osteotomy model.Bone & joint research · 2025Article
- The Home Use of Probiotics and Paraprobiotics for the Maintenance of Tongue Eubiosis: A Case Report.Case reports in dentistry · 2025Article
- Higher solubility and lower onset temperature of protein denaturation increase the osteoconductive capacity of collagen membranes: A preclinical in vivo study.Clinical oral implants research · 2024Article
- Comparison of Bone Graft Preparations to Treat a Critical Bone Defect on a Rodent Animal Model.Revista brasileira de ortopedia · 2024Article
- Human versus Rat PRF on Collagen Membranes: A Pilot Study of Mineralization in Rat Calvaria Defect Model.Bioengineering (Basel, Switzerland) · 2024Article
- Active and Passive Mineralization of Bio-GideJournal of functional biomaterials · 2024Article
- Bone regeneration driven by a nano-hydroxyapatite/chitosan composite bioaerogel for periodontal regeneration.Frontiers in bioengineering and biotechnology · 2024Article
- Bone Allograft Acid Lysates Change the Genetic Signature of Gingival Fibroblasts.International journal of molecular sciences · 2023Article
- Article
- Compositions and Structural Geometries of Scaffolds Used in the Regeneration of Cleft Palates: A Review of the Literature.Polymers · 2022Review
- Osteoconductive Properties of a Volume-Stable Collagen Matrix in Rat Calvaria Defects: A Pilot Study.Biomedicines · 2021Article
- Osteoconductive properties of upside-down bilayer collagen membranes in rat calvarial defects.International journal of implant dentistry · 2021Article
- Acid bone lysates reduce bone regeneration in rat calvaria defects.Journal of biomedical materials research. Part A · 2021Article
- Article
- Cleaning Teeth Reduces the Inflammatory Response of Macrophages to Acid Dentine Lysate.International journal of molecular sciences · 2020Article
- Proteomic Analysis of Porcine-Derived Collagen Membrane and Matrix.Materials (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 4 countries.
Funding
Abstract
Acid bone lysates (ABLs) represent the growth factors and other molecules released during autologous graft resorption. However, the impact of these bone-derived growth factors on the healing of bone defects has not yet been investigated. The aim of the present study was, therefore, to examine the impact of ABLs adsorbed to collagen membranes on bone regeneration. To this end, in 16 female Sprague Dawley rats, a standardized 5-mm-diameter critical size defect on the calvarial bone was created. The defects were covered with collagen membranes that had been soaked either in serum-free media or ABLs followed by lyophilization. After a healing period of 4 weeks, micro-computed tomography (μCT) and histological analyses by means of undecalcified thin ground sections were performed. μCT analysis of the inner 4 mm of the calvaria defect showed a greater bone defect coverage in the control group when compared to ABL group, 29.8% (confidence interval [CI]: 17.7-50.3) versus 5.6% (CI: 1.0-29.8, p = .03), respectively. Moreover, we found significantly more absolute bone volume (BV) in the control group when compared to ABL group, 0.59 mm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.