Evidence map›Paper›PMID 32608097›Full record

ArticleJournal of prosthodontics : official journal of the American College of Prosthodontists2020

Comparison of In Vitro Inactivation of SARS CoV-2 with Hydrogen Peroxide and Povidone-Iodine Oral Antiseptic Rinses.

Avinash S Bidra, Jesse S Pelletier, Jonna B Westover, Samantha Frank, Seth M Brown, Belachew Tessema

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of prosthodontics : official journal of the American College of Prosthodontists, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06272019 (Alternative Application Methods of Pre-procedural Povidone Iodine Mouthrinse), which is not on this map. Cited by 79 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06272019 nacompletednot on this mapstarted 2023, after this paper: background citation

Alternative Application Methods of Pre-procedural Povidone Iodine Mouthrinse

TypeinterventionalSponsorChulalongkorn UniversityRan2023 to 2024Enrolled25ConditionsThe Retention of Iodine in Saliva Over the Time, The Comparison of Iodine in Saliva Between Gargle and SwabArmsIodine gargle
3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  5. Disinfection methods against SARS-CoV-2: a systematic review.The Journal of hospital infection · 2022
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  6. Surface contamination with SARS-CoV-2: A systematic review.The Science of the total environment · 2021
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Avinash S BidraDepartment of Reconstructive Sciences, University of Connecticut Health Center, Farmington, CT.ORCID https://orcid.org/0000-0001-8831-8096
Jesse S PelletierOcean Ophthalmology Group, Miami, FL.
Jonna B WestoverThe Institute for Antiviral Research at Utah State University, Logan, UT.
Samantha FrankDepartment of Otolaryngology, University of Connecticut Health Center, Farmington, CT.
Seth M BrownDepartment of Otolaryngology, University of Connecticut Health Center, Farmington, CT.
Belachew TessemaDepartment of Otolaryngology, University of Connecticut Health Center, Farmington, CT.

Funding

Veloce Biopharma, Ft Lauderdale, Florida
6 · The paper itself

Abstract

purposeTo evaluate the in vitro inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with hydrogen peroxide (H MATERIALS AND

methodsSARS-CoV-2, USA-WA1/2020 strain virus stock was prepared prior to testing by growing in Vero 76 cells. The culture media for prepared virus stock was minimum essential medium (MEM) with 2% fetal bovine serum (FBS) and 50 µg/mL gentamicin. Test compounds consisting of PVP-I oral rinse solutions and H

resultsAfter the 15-second and 30-second contact times, PVP-I oral antiseptic rinse at all 3 concentrations of 0.5%, 1.25%, and 1.5% completely inactivated SARS-CoV-2. The H

conclusionsSARS-CoV-2 virus was completely inactivated by PVP-I oral antiseptic rinse in vitro, at the lowest concentration of 0.5 % and at the lowest contact time of 15 seconds. Hydrogen peroxide at the recommended oral rinse concentrations of 1.5% and 3.0% was minimally effective as a viricidal agent after contact times as long as 30 seconds. Therefore, preprocedural rinsing with diluted PVP-I in the range of 0.5% to 1.5% may be preferred over hydrogen peroxide during the COVID-19 pandemic.

Indexed as

Anti-Infective Agents, LocalBetacoronavirusCoronavirus InfectionsCOVID-19Pneumonia, ViralSevere acute respiratory syndrome-related coronavirusHumansHydrogen PeroxidePandemicsPovidone-IodineSARS-CoV-2Anti-Infective Agents, LocalHydrogen PeroxidePovidone-IodineCorona virusdental safetyhydrogen peroxideoral rinsepovidone-iodineSARS-CoV-2

Identifiers

PMID32608097
PMCPMC7361576

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.