Evidence map›Paper›PMID 32607960›Full record

ArticleJournal of gastrointestinal cancer2021

Does Neutrophil-to-Lymphocyte Ratio (NLR) Predict Pathologic Response to Neoadjuvant Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma?

Santhosh Anand, Gajendra Bhati, Ramprakash Gurram, Senthil Gnanasekaran, Vikram Kate, Biju Pottakkat, Raja Kalayarasan

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07138053 (The Impact of Multimodal Balancing Anesthesia vs Opioid Free Anesthesia on Postoperative Pain Intensity and Stress Response After Open Gynecology Surgery), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07138053 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

The Impact of Multimodal Balancing Anesthesia vs Opioid Free Anesthesia on Postoperative Pain Intensity and Stress Response After Open Gynecology Surgery

TypeinterventionalSponsorCantonal Hospital ZenicaRan2025 to 2026Enrolled80ConditionsOpioid Free Anesthesia, Stress Response, Postoperative PainArmsOFA group
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Santhosh AnandDepartment of Surgical Gastroenterology, JIPMER, Room no 5442, Fourth floor, Superspeciality block, Puducherry, 605006, India.
Gajendra BhatiDepartment of Surgical Gastroenterology, JIPMER, Room no 5442, Fourth floor, Superspeciality block, Puducherry, 605006, India.
Ramprakash GurramDepartment of Surgical Gastroenterology, JIPMER, Room no 5442, Fourth floor, Superspeciality block, Puducherry, 605006, India.
Senthil GnanasekaranDepartment of Surgical Gastroenterology, JIPMER, Room no 5442, Fourth floor, Superspeciality block, Puducherry, 605006, India.
Vikram KateGeneral surgery, JIPMER, Puducherry, India.
Biju PottakkatDepartment of Surgical Gastroenterology, JIPMER, Room no 5442, Fourth floor, Superspeciality block, Puducherry, 605006, India.
Raja KalayarasanDepartment of Surgical Gastroenterology, JIPMER, Room no 5442, Fourth floor, Superspeciality block, Puducherry, 605006, India. kalayarasanraja@yahoo.com.
Jawaharlal Institute of Post Graduate Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeoadjuvant chemoradiotherapy (nCRT), followed by surgery, is the current standard of care for patients with locally advanced esophageal squamous cell carcinoma. However, up to 30% of the patients do not respond to nCRT. Hence, a simple, cost-effective marker to predict response before initiation of nCRT is needed. Neutrophil-to-lymphocyte ratio (NLR) has been reported as a prognostic marker in various cancers. However, its role as a predictive marker in patients with esophageal SCC planned for nCRT has not been prospectively analyzed. MATERIALS AND

methodsAll consecutive patients with locally advanced (T1N1 and T2-T4a with or without nodal involvement) SCC planned for nCRT (CROSS protocol) followed by esophagectomy with total two field lymphadenectomy between December 2013 and December 2019 were included in this prospective analytical cohort study. NLR was calculated 1 week before starting the nCRT and was correlated with the histopathological response [Mandard tumor regression grade (TRG)].

resultsOf the 216 patients with esophageal cancer evaluated during the study period, 57 patients with SCC who fulfilled the inclusion criteria were included. A good pathologic response (TRG 1 and 2) to nCRT was seen in 28 (49.1%) patients. Using a ROC curve, the optimal cutoff value of pretherapy NLR for predicting good pathologic response was 2.33. With an NLR cutoff value of 2.33, 53.3% of patients had a good pathologic response to nCRT compared with 47.6% patients with NLR ≥ 2.33 (P = 0.77).

conclusionIn patients with locally advanced esophageal SCC, NLR is not a useful marker to predict pathologic response to nCRT.

Indexed as

LymphocytesNeutrophilsAdultAgedAntineoplastic Combined Chemotherapy ProtocolsChemoradiotherapy, AdjuvantDose Fractionation, RadiationEsophageal MucosaEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaEsophagectomyFeasibility StudiesFemaleHumansLymphocyte CountMaleEsophageal cancerNeoadjuvant therapyNeutrophil-to-lymphocyte ratioSquamous cell carcinoma

Identifiers

PMID32607960
OpenAlexW3040096768

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.