Evidence map›Paper›PMID 32607928›Full record

ArticleJournal of general internal medicine2021

Risk Factors for Mortality in Patients with COVID-19 in New York City.

Takahisa Mikami, Hirotaka Miyashita, Takayuki Yamada, Matthew Harrington, Daniel Steinberg, Andrew Dunn, Evan Siau

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of general internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 24 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed, 24 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

147 citing papers in PubMed, 24 syntheses or guidelines pooled it.

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  5. Associations between Serum Interleukins (IL-1BioMed research international · 2022
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  15. Asthma in patients with coronavirus disease 2019: A systematic review and meta-analysis.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2021
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  16. Meta-analysis of cardiac markers for predictive factors on severity and mortality of COVID-19.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
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  18. Effect of hydroxychloroquine with or without azithromycin on the mortality of coronavirus disease 2019 (COVID-19) patients: a systematic review and meta-analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2021
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87 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Takahisa MikamiDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hirotaka MiyashitaDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Takayuki YamadaDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Matthew HarringtonDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Daniel SteinbergDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Andrew DunnDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Evan SiauDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Evan.Siau@mountsinai.org.ORCID http://orcid.org/0000-0002-9765-4187

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNew York City emerged as an epicenter of the coronavirus disease 2019 (COVID-19) pandemic.

objectiveTo describe the clinical characteristics and risk factors associated with mortality in a large patient population in the USA.

designRetrospective cohort study.

participants6493 patients who had laboratory-confirmed COVID-19 with clinical outcomes between March 13 and April 17, 2020, who were seen in one of the 8 hospitals and/or over 400 ambulatory practices in the New York City metropolitan area MAIN MEASURES: Clinical characteristics and risk factors associated with in-hospital mortality. KEY

resultsA total of 858 of 6493 (13.2%) patients in our total cohort died: 52/2785 (1.9%) ambulatory patients and 806/3708 (21.7%) hospitalized patients. Cox proportional hazard regression modeling showed an increased risk of in-hospital mortality associated with age older than 50 years (hazard ratio [HR] 2.34, CI 1.47-3.71), systolic blood pressure less than 90 mmHg (HR 1.38, CI 1.06-1.80), a respiratory rate greater than 24 per min (HR 1.43, CI 1.13-1.83), peripheral oxygen saturation less than 92% (HR 2.12, CI 1.56-2.88), estimated glomerular filtration rate less than 60 mL/min/1.73m

conclusionsAmong patients with COVID-19, older age, male sex, hypotension, tachypnea, hypoxia, impaired renal function, elevated D-dimer, and elevated troponin were associated with increased in-hospital mortality and hydroxychloroquine use was associated with decreased in-hospital mortality.

Indexed as

Hospital MortalityAdultAgedAged, 80 and overAge FactorsAmbulatory CareCase-Control StudiesComorbidityCOVID-19FemaleHospitalizationHumansKaplan-Meier EstimateMaleMiddle AgedNew York City

Identifiers

PMID32607928
PMCPMC7325642

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.