Evidence map›Paper›PMID 32607910›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2020

Hypervitaminosis A is associated with immunological non-response in HIV-1-infected adults: a case-control study.

Hugues Melliez, Michel Prost, Hélène Behal, Nathalie Neveux, Jean-François Benoist, Isabelle Kim, Sylvie Mazzella, Vincent Derdour, Evelyne Sauser, Olivier Robineau and 4 more

Abstract read
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In one paragraph

Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Hugues MelliezHôpital Gustave Dron, Service universitaire des maladies infectieuses et du voyageur, Tourcoing, France. hugues.melliez@outlook.fr.ORCID http://orcid.org/0000-0002-6841-5494
Michel ProstLaboratoire LARA SPIRAL, Couternon, France.
Hélène BehalCHU Lille, ULR 2694 - METRICS: Évaluation des technologies de santé et des pratiques médicales, University Lille, F-59000, Lille, France.
Nathalie NeveuxService de Biochimie, Hôpital Cochin, APHP et Service de Nutrition, Faculté de Pharmacie, Université de Paris, Paris, France.
Jean-François BenoistBiochimie hormonologie, Hôpital Universitaire Robert Debré APHP, Paris, France.
Isabelle KimCentre de Pathologies-Biologie, CHRU de Lille, Lille, France.
Sylvie MazzellaHôpital Gustave Dron, Service universitaire des maladies infectieuses et du voyageur, Tourcoing, France.
Vincent DerdourHôpital Gustave Dron, Service universitaire des maladies infectieuses et du voyageur, Tourcoing, France.
Evelyne SauserLaboratoire d'Analyses Médicales, CH Dron, Tourcoing, France.
Olivier RobineauHôpital Gustave Dron, Service universitaire des maladies infectieuses et du voyageur, Tourcoing, France.
Eric SennevilleHôpital Gustave Dron, Service universitaire des maladies infectieuses et du voyageur, Tourcoing, France.
Luc CynoberService de Biochimie, Hôpital Cochin, APHP et Service de Nutrition, Faculté de Pharmacie, Université de Paris, Paris, France.
Raphaël BiekreHôpital Gustave Dron, Service universitaire des maladies infectieuses et du voyageur, Tourcoing, France.
David SeguyU1286 - Infinite - Institute for Translational Research in Inflammation, University Lille, F-59000, Lille, France.
Centre Hospitalier de Tourcoing · FRCentre Hospitalier Universitaire de Lille · FRUniversité Paris Cité · FRInserm · FRLaboratoires Spiral (France) · FRUniversité Paris-Sud · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For people living with HIV, determinants of immunological non-response (INR) to combined antiretroviral therapy (cART) have not been fully elucidated. In a case-control study, we evaluated the influence of the nutritional and antioxidant status in HIV-1 adults whose cART was initiated between January 2001 and December 2013. Cases had persistent CD4 counts < 350/μL vs. > 350/μL for controls, after at least 2 years of cART with persistent viral loads (VL) < 50 copies/mL. Twelve cases and twenty-eight control subjects with the same CD4 count at cART initiation were compared for their nutritional and antioxidant status after age adjustment at dosage assessment. Patients were predominantly male (70%), Caucasian (82%) and at AIDS stage (62%). The median age was 53, and the median CD4 count was 245/mm

Indexed as

HIV-1HIV InfectionsAdolescentAdultCase-Control StudiesCD4 Lymphocyte CountFemaleFranceHumansHypervitaminosis AMaleMiddle AgedViral LoadYoung AdultAntioxidant statusHIVHypervitaminosis AImmunological non-responseNutrition

Identifiers

PMID32607910
OpenAlexW3040133009

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.