ArticleAging clinical and experimental research2021
Clinical determinants of low handgrip strength and its decline in the oldest old: the Leiden 85-plus Study.
Article in Aging clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Hand grip strength and loss of independence in Indigenous and non-Indigenous New Zealand octogenarians-the LiLACS NZ cohort study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Overactive Bladder Symptoms as a Predictor of Longitudinal Decline in Grip Strength in Community-Dwelling Men: A 4-Year Longitudinal Study.Lower urinary tract symptoms · 2026Article
- Bidirectional association between grip strength and cognitive function in Chinese older adults: a nationwide cohort study.BMC public health · 2025Article
- Handgrip strength is associated with cognitive function in older patients with stage 3-5 chronic kidney disease: results from the NHANES.Scientific reports · 2024Article
- Do lifestyle, anthropometric and demographic factors associated with muscle strength differ in a UK and Japanese cohort? An exploratory analysis.Aging clinical and experimental research · 2023Article
- Biological ageing and the risk of decreased handgrip strength among community-dwelling older adult Indians: a cross-sectional study.BMC geriatrics · 2023Article
- Interactive effect of serum uric acid and handgrip strength on all-cause mortality among Japanese community-dwelling people.Metabolism open · 2023Article
- Article
- Dynapenia in all-cause mortality and its relationship with sedentary behavior in community-dwelling older adults.Sports medicine and health science · 2022Article
- 12-month survival in nonagenarians inside the Mugello study: on the way to live a century.BMC geriatrics · 2022Article
- Physical Performance, Cardiovascular Health and Psychosocial Wellbeing in Older Adults Compared to Oldest-Old Residential Seniors.International journal of environmental research and public health · 2022Article
- Gender and education inequalities in dynapenia-free life expectancy: ELSI-Brazil.Revista de saude publica · 2022Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAge-related decline in muscle strength, dynapenia, is linked to serious adverse health outcomes. Evidence on the determinants of muscle strength decline in the oldest old is lacking.
aimsTo identify clinical variables associated with handgrip strength and its change over a 4-year period in an oldest old cohort.
methodsWe included 555 participants from the Leiden 85-plus Study, a prospective population-based study of 85-year-old inhabitants of Leiden, the Netherlands. Handgrip strength was assessed at age 85 and 89 years. Anthropometry, mental status, functional performance, and biochemical variables were obtained at baselines. Significant univariates were included into multivariable regression models to extract the final predictive variables.
resultsHandgrip strength for men and women at age 85 years was 30.6 kg (SD 8.2) and 18.7 kg (SD, 5.5), respectively. In the cross-sectional analysis, body height and weight were positively associated with handgrip strength in both genders. Higher functional performance was associated with stronger handgrip strength in women. Mean absolute handgrip strength decline over 4 years was greater for men than women (- 6.1 kg (SD, 5.2) vs. - 3.4 kg (SD, 4.1), p < 0.001). Men with better baseline cognitive functioning had smaller decline in handgrip strength.
conclusionsThis study further strengthens evidence linking functional and cognitive performances to muscle strength in the oldest old. Future research is needed to ascertain causality and determine if these markers represent potential targets for intervention.
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