Evidence map›Paper›PMID 32607817›Full record

SynthesisNeuropsychology review2020

The Developmental Trajectory of Cancer-Related Cognitive Impairment in Breast Cancer Patients: A Systematic Review of Longitudinal Neuroimaging Studies.

Helena Sousa, Susana Almeida, João Bessa, M Graça Pereira

Open access · goldAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neuropsychology review, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 5 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Helena SousaFamily Health & Illness Research Group, School of Psychology, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.ORCID 0000-0002-0832-0004
Susana AlmeidaResearch Center in Psychology (CIPsi), School of Psychology, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.
João BessaResearch Center in Psychology (CIPsi), School of Psychology, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.ORCID 0000-0001-6385-2452
M Graça PereiraFamily Health & Illness Research Group, School of Psychology, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal. gracep@psi.uminho.pt.ORCID 0000-0001-7987-2562
University of Minho · PTInstituto Português de Oncologia Francisco Gentil · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This systematic review explored the neurobiological mechanisms underlying the clinical time course of cancer-related cognitive impairment (CRCI) in breast cancer patients through the review of longitudinal neuroimaging studies. Before chemotherapy, results reported no evidence for neuropsychological, structural (gray matter) and brain perfusion changes. However, functional brain alterations were evident and revealed a frontoparietal hyperactivation during working memory tasks. Fatigue and number of days since surgery were the two suggested confounding factors. Acutely after chemotherapy, this review found no evidence for neuropsychological changes while suggesting a pattern of frontal structural, perfusion and functional brain abnormalities. These findings seemed to be dependent on age, menopausal status at baseline, and fMRI task performed. Years after chemotherapy, results revealed evidence of partial neuropsychological, structural, and functional brain recovery. Regarding brain abnormality, this review suggested that it may begin quite early in the disease course, be more prominent shortly after chemotherapy and partially recover over time. Several hypotheses underlying these changes were discussed. The present review also provided important information for developing a time-specific treatment and prevention strategies and for the consideration of functional neuroimaging as a relevant tool for CRCI diagnosis, clinical monitoring, and intervention studies. The findings also suggested the need to implement studies with longitudinal designs, including a pre-treatment assessment, since cross-sectional studies were not able to detect this pattern of recovery over time, supporting only the theory of brain abnormalities, in breast cancer survivors.

Indexed as

AdultBrainBreast NeoplasmsChemotherapy-Related Cognitive ImpairmentCognitive DysfunctionCross-Sectional StudiesFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMemory, Short-TermMiddle AgedNeuroimagingNeuropsychological TestsBreast cancerCancer-related cognitive impairmentCognitionfMRIMRINeuroimaging

Identifiers

PMID32607817
OpenAlexW3040509731

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.