ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2021
Is there a role for chemotherapy and radiation in the treatment of patients with low-grade myofibroblastic sarcoma?
Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Oral and Maxillofacial Low-Grade Myofibroblastic Sarcoma: A Systematic Review.Head and neck pathology · 2025Pooled it
- Myofibrosarcoma of the maxillary sinus with orbital floor involvement: a case report.Journal of surgical case reports · 2026Article
- Surgical management and outcomes of spinal low-grade myofibroblastic sarcoma: a single-center case series and literature review.BMC surgery · 2026Review
- Synchronous low-grade myofibroblastic sarcoma and small cell lung cancer in a patient with situs inversus totalis: a case report and literature review.Frontiers in oncology · 2026Article
- Low-Grade Myofibroblastic Sarcoma of the tongue: A case report and literature review.Journal of clinical and experimental dentistry · 2025Article
- Early diagnosis and treatment of low-grade myofibroblastic sarcoma in the left distal femur: a case report and literature review.BMC musculoskeletal disorders · 2025Review
- Significant increase in calcification and ossification observed after the second relapse of low-grade myofibroblast sarcoma treated with radiotherapy followed by anlotinib and toripalimab: a case report.Frontiers in immunology · 2025Article
- Case Report: First case of low-grade myofibroblastic sarcoma of the vulva during pregnancy.Frontiers in oncology · 2025Article
- Deep Convolutional Neural Network for Accurate Classification of Myofibroblastic Lesions on Patch-Based Images.Head and neck pathology · 2024Article
- Low-grade myofibrosarcoma of the maxillary sinus: Two case reports.World journal of clinical oncology · 2024Article
- Indolent growth of low‑grade myofibroblastic sarcoma of the knee with the resemblance of a benign lesion: A case report.Oncology letters · 2024Article
- Myofibroblastic sarcoma in breast: a case report and literature review.Frontiers in oncology · 2024Article
- Anlotinib in combination with pembrolizumab for low-grade myofibroblastic sarcoma of the pancreas: A case report.World journal of clinical cases · 2023Article
- Article
- Low-grade myofibroblastic sarcoma of the mandible: A rare tumour of childhood.Journal of oral and maxillofacial pathology : JOMFP · 2023Article
- Management of a Highly Vascular Low-grade Myofibroblastic Sarcoma of the Mandible.Plastic and reconstructive surgery. Global open · 2022Article
- Surgical treatment and long-term outcomes of low-grade myofibroblastic sarcoma: a single-center case series of 15 patients.World journal of surgical oncology · 2021Article
- Low-Grade Myofibroblastic Sarcoma of the Oral Cavity: A Report of Three Cases Illustrating an Emerging Disease in Children.Dermatopathology (Basel, Switzerland) · 2021Article
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
purposeLow-grade myofibroblastic sarcoma (LGMS) is a rare entity with a predilection for the head and neck. There are still no optimal treatment strategies for patients with LGMS. We retrospectively investigated the efficacies of chemotherapy and radiation treatment for patients with LGMS. METHODS/PATIENTS: We obtained data from the Surveillance, Epidemiology, and End Result (SEER) database for 96 patients diagnosed with LGMS between 2001 and 2015. We used Kaplan-Meier curves and log-rank tests to estimate overall survival (OS) and Cox proportional hazard regression to identify prognostic factors.
resultsThe median age of the patients was 55.0 years. Twenty-two of the patients had LGMS in the head and neck region. Of the 96 patients, 86 (89.6%) received surgical treatment, 28 (29.2%) received radiation treatment, and 20 (10.4%) received chemotherapy. The mean OS was 125.2 [95% confidence interval (CI) 106.3-144.2] months. The 1, 3, 5, and 10-year OS rates were 88%, 77%, 70%, and 59%, respectively. Age greater than 60 years, positive nodal status, and no surgical treatment were independent prognostic factors for patients with LGMS, whereas chemotherapy and radiation treatment were not.
conclusionsSurgical resection is the most effective therapy for LGMS. Chemotherapy and radiation had limited effects on survival improvement for patients with LGMS. Therefore, chemotherapy and/or radiation therapy should not be routinely performed in LGMS, especially for those with negative margins after surgery.
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