ArticleEJNMMI physics2020
Performance assessment of the 2 γpositronium imaging with the total-body PET scanners.
Article in EJNMMI physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 70 citations in OpenAlex.
- Feasibility simulation study of positronium lifetime imaging with the Biograph Vision Quadra and J-PET tomographs.EJNMMI physics · 2026Article
- First positronium lifetime imaging usingScientific reports · 2026Article
- Phantom imaging demonstration of positronium lifetime with a long axial field-of-view PET/CT andEJNMMI physics · 2025Article
- Nonmaximal entanglement of photons from positron-electron annihilation demonstrated using a plastic PET scanner.Science advances · 2025Article
- Realistic total-body J-PET geometry optimization: Monte Carlo study.Medical physics · 2025Article
- A statistical reconstruction algorithm for positronium lifetime imaging using time-of-flight positron emission tomography.IEEE transactions on radiation and plasma medical sciences · 2025Article
- First positronium lifetime imaging with scandium-44 on a long axial field-of-view PET/CT.Frontiers in nuclear medicine · 2025Article
- Fast high-resolution lifetime image reconstruction for positron lifetime tomography.Communications physics · 2025Article
- High-resolution positronium lifetime tomography by the method of moments.Physics in medicine and biology · 2024Article
- Comparative analysis of positron emitters for theranostic applications based on small bioconjugates highlightingEJNMMI physics · 2024Article
- Positronium image of the human brain in vivo.Science advances · 2024Article
- Positronium lifetime validation measurements using a long-axial field-of-view positron emission tomography scanner.EJNMMI physics · 2024Article
- SPLIT: Statistical Positronium Lifetime Image Reconstruction via Time-Thresholding.IEEE transactions on medical imaging · 2024Article
- Enhanced positronium lifetime imaging through two-component reconstruction in time-of-flight positron emission tomography.Frontiers in physics · 2024Article
- Inverse shielding and mutual exclusion for PET-MR hybrid imaging concerning induced positronium hyperfine splits radiations.Scientific reports · 2023Article
- 3D melanoma spheroid model for the development of positronium biomarkers.Scientific reports · 2023Article
- Efficiency determination of J-PET: first plastic scintillators-based PET scanner.EJNMMI physics · 2023Article
- Developing a novel positronium biomarker for cardiac myxoma imaging.EJNMMI physics · 2023Article
- Experience and new prospects of PET imaging for ion beam therapy monitoring.Zeitschrift fur medizinische Physik · 2023Review
- The properties of the positronium lifetime image reconstruction based on maximum likelihood estimation.Bio-algorithms and med-systems · 2023Article
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Authors and funding
42 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn living organisms, the positron-electron annihilation (occurring during the PET imaging) proceeds in about 30% via creation of a metastable ortho-positronium atom. In the tissue, due to the pick-off and conversion processes, over 98% of ortho-positronia annihilate into two 511 keV photons. In this article, we assess the feasibility for reconstruction of the mean ortho-positronium lifetime image based on annihilations into two photons. The main objectives of this work include the (i) estimation of the sensitivity of the total-body PET scanners for the ortho-positronium mean lifetime imaging using 2γ annihilations and (ii) estimation of the spatial and time resolution of the ortho-positronium image as a function of the coincidence resolving time (CRT) of the scanner.
methodsSimulations are conducted assuming that radiopharmaceutical is labeled with
resultsThe estimated total-body PET sensitivity for the registration and selection of image forming triple coincidences (2γ+γ
conclusionsOrtho-positronium mean lifetime imaging based on the annihilations into two photons and prompt gamma is shown to be feasible with the advent of the high sensitivity total-body PET systems and time resolution of the order of tens of picoseconds.
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