Evidence map›Paper›PMID 32607579›Full record

ArticleNeuro-oncology2020

European genetic ancestry associated with risk of childhood ependymoma.

Chenan Zhang, Quinn T Ostrom, Helen M Hansen, Julio Gonzalez-Maya, Donglei Hu, Elad Ziv, Libby Morimoto, Adam J de Smith, Ivo S Muskens, Cassie N Kline and 12 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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  17. Epidemiology of Brain and Other CNS Tumors.Current neurology and neuroscience reports · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 8 institutions in 2 countries.

Chenan ZhangDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.
Quinn T OstromDepartment of Medicine, Section of Epidemiology and Population Sciences, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
Helen M HansenDepartment of Neurological Surgery, University of California San Francisco, San Francisco, California, USA.
Julio Gonzalez-MayaDepartment of Neurological Surgery, University of California San Francisco, San Francisco, California, USA.
Donglei HuDivision of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Elad ZivDivision of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Libby MorimotoSchool of Public Health, University of California Berkeley Berkeley, California, USA.
Adam J de SmithCenter for Genetic Epidemiology, University of Southern California, Los Angeles, California, USA.
Ivo S MuskensCenter for Genetic Epidemiology, University of Southern California, Los Angeles, California, USA.
Cassie N KlineDivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of California San Francisco, San Francisco, California, USA.
Zalman VaksmanDepartment of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Hakon HakonarsonCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Sharon J DiskinDepartment of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Carol KruchkoDepartment of Neurology, University of California San Francisco, San Francisco, California, USA.
Jill S Barnholtz-SloanDepartment of Population and Quantitative Health Sciences and Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Vijay RamaswamyThe Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Francis Ali-OsmanDepartment of Neurosurgery and Duke Cancer Institute, Duke University School of Medicine, Durham, North Carolina, USA.
Melissa L BondyDepartment of Medicine, Section of Epidemiology and Population Sciences, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
Michael D TaylorThe Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Catherine MetayerSchool of Public Health, University of California Berkeley Berkeley, California, USA.
Joseph L WiemelsCenter for Genetic Epidemiology, University of Southern California, Los Angeles, California, USA.
Kyle M WalshDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.
University of California, San Francisco · USChildren's Hospital of Philadelphia · USUniversity of Southern California · USBaylor College of Medicine · USBerkeley Public Health Division · USDuke University · USHospital for Sick Children · CACase Western Reserve University · US

Funding

Targeted Alpha-Particle Radiotheraphy of Brain Tumors with 211At-81C6 AntibodyP50CA190991 · NCI · DUKE UNIVERSITY · PI SAMPSON, JOHN H. · 2014 to 2023
$20.8M
Training Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6M
Genetic Susceptibility to Pediatric Glioma inIndividuals and Diverse populationsR01CA194189 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WALSH, KYLE M, WIEMELS, JOSEPH LEO · 2015 to 2020
$5.0M
Genome-Wide Association Study of Childhood Leukemia by Hispanic StatusR01CA155461 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MA, XIAOMEI, WIEMELS, JOSEPH LEO · 2011 to 2014
$4.1M
NCCDPHP CDC HHS NU58DP006344NCI NIH HHS HHSN261201800009CNCI NIH HHS HHSN261201800009INCI NIH HHS HHSN261201800015CNCI NIH HHS HHSN261201800015INCI NIH HHS HHSN261201800032CNCI NIH HHS HHSN261201800032INCI NIH HHS P50 CA190991NCI NIH HHS R01 CA155461NCI NIH HHS R01 CA194189NCI NIH HHS T32 CA151022
6 · The paper itself

Abstract

backgroundEpendymoma is a histologically defined central nervous system tumor most commonly occurring in childhood. Population-level incidence differences by race/ethnicity are observed, with individuals of European ancestry at highest risk. We aimed to determine whether extent of European genetic ancestry is associated with ependymoma risk in US populations.

methodsIn a multi-ethnic study of Californian children (327 cases, 1970 controls), we estimated the proportions of European, African, and Native American ancestry among recently admixed Hispanic and African American subjects and estimated European admixture among non-Hispanic white subjects using genome-wide data. We tested whether genome-wide ancestry differences were associated with ependymoma risk and performed admixture mapping to identify associations with local ancestry. We also evaluated race/ethnicity-stratified ependymoma incidence data from the Central Brain Tumor Registry of the United States (CBTRUS).

resultsCBTRUS data revealed that African American and Native American children have 33% and 36%, respectively, reduced incidence of ependymoma compared with non-Hispanic whites. In genetic analyses, a 20% increase in European ancestry was associated with a 1.31-fold higher odds of ependymoma among self-reported Hispanics and African Americans (95% CI: 1.08-1.59, Pmeta = 6.7 × 10-3). Additionally, eastern European ancestral substructure was associated with increased ependymoma risk in non-Hispanic whites (P = 0.030) and in Hispanics (P = 0.043). Admixture mapping revealed a peak at 20p13 associated with increased local European ancestry, and targeted fine-mapping identified a lead variant at rs6039499 near RSPO4 (odds ratio = 1.99; 95% CI: 1.45-2.73; P = 2.2 × 10-5) but which was not validated in an independent set of posterior fossa type A patients.

conclusionsInterethnic differences in ependymoma risk are recapitulated in the genomic ancestry of ependymoma patients, implicating regions to target in future association studies.

Indexed as

EpendymomaBlack or African AmericanChildFemaleHispanic or LatinoHumansMaleUnited StatesWhite Peopledisparitiesependymomaethnicitygenetic ancestrypediatric cancerrace

Identifiers

PMID32607579
PMCPMC7846152
OpenAlexW3033204265

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.