Trial reportAmerican journal of critical care : an official publication, American Association of Critical-Care Nurses2020
Relationship Between Intensive Care Unit Delirium Severity and 2-Year Mortality and Health Care Utilization.
Trial report in American journal of critical care : an official publication, American Association of Critical-Care Nurses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Mortality Risk Following Delirium in Older Inpatients: A Systematic Review and Meta-Analysis.Worldviews on evidence-based nursing · 2025Pooled it
- Haloperidol in treating delirium, reducing mortality, and preventing delirium occurrence: Bayesian and frequentist meta-analyses.Critical care (London, England) · 2025Pooled it
- Delirium severity does not differ between medical and surgical intensive care units after adjusting for medication use.Scientific reports · 2022Trial
- Nurse-led family participatory support intervention on clinical outcomes in ICU patients: a prospective quasi-experimental study.Critical care (London, England) · 2026Article
- Characteristics and Risk Factors for Delirium in Critically Ill Cardiac Surgery Patients: An Observational Study.Nursing reports (Pavia, Italy) · 2026Article
- Harnessing the Power of Technology to Transform Delirium Severity Measurement in the Intensive Care Unit: Protocol for a Prospective Cohort Study.JMIR research protocols · 2025Article
- The frequency of sepsis-associated delirium in intensive care unit and its effect on nurse workload.Journal of clinical nursing · 2025Article
- Point-of-Care Electroencephalography in Acute Neurological Care: A Narrative Review.Neurology international · 2025Review
- Article
- Advancing specificity in delirium: The delirium subtyping initiative.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Clinical Features of Delirium among Patients in the Intensive Care Unit According to Motor Subtype Classification: A Retrospective Longitudinal Study.Yonsei medical journal · 2023Article
- Long-term mortality of critically ill patients with cancer and delirium who survived to discharge: a retrospective cohort study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023Article
- Delirium detection using GAMMA wave and machine learning: A pilot study.Research in nursing & health · 2022Article
- Dynamic Delirium Severity Trajectories and Their Association With 2-Year Healthcare Utilization and Mortality Outcomes.Critical care explorations · 2021Article
- Natural language processing to assess the epidemiology of delirium-suggestive behavioural disturbances in critically ill patients.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2021Article
- Cluster nursing can reduce postoperative delirium and improve the negative emotions and quality of life of elderly ICU patients.American journal of translational research · 2021Article
- Delirium severity and outcomes of critically ill COVID-19 patients.Critical care scienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCritical care patients with delirium are at an increased risk of functional decline and mortality long term.
objectiveTo determine the relationship between delirium severity in the intensive care unit and mortality and acute health care utilization within 2 years after hospital discharge.
methodsA secondary data analysis of the Pharmacological Management of Delirium and Deprescribe randomized controlled trials. Patients were assessed twice daily for delirium or coma using the Richmond Agitation-Sedation Scale and the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Delirium severity was measured using the CAM-ICU-7. Mean delirium severity (from time of randomization to discharge) was categorized as rapidly resolving, mild to moderate, or severe. Cox proportional hazards regression was used to model time to death, first emergency department visit, and rehospitalization. Analyses were adjusted for age, sex, race, Charlson Comorbidity Index, Acute Physiology and Chronic Health Evaluation II score, discharge location, diagnosis, and intensive care unit type.
resultsOf 434 patients, those with severe delirium had higher mortality risk than those with rapidly resolving delirium (hazard ratio 2.21; 95% CI, 1.35-3.61). Those with 5 or more days of delirium or coma had higher mortality risk than those with less than 5 days (hazard ratio 1.52; 95% CI, 1.07-2.17). Delirium severity and number of days of delirium or coma were not associated with time to emergency department visits and rehospitalizations.
conclusionIncreased delirium severity and days of delirium or coma are associated with higher mortality risk 2 years after discharge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.