Trial reportThe Yale journal of biology and medicine2020
Kratom and Pain Tolerance: A Randomized, Placebo-Controlled, Double-Blind Study.
Trial report in The Yale journal of biology and medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Qualitative content analysis of public responses to an FDA inquiry on the impact of scheduling changes to kratom.The International journal on drug policy · 2022Pooled it
- A systematic review of (pre)clinical studies on the therapeutic potential and safety profile of kratom in humans.Human psychopharmacology · 2022Pooled it
- An exploratory study of the safety profile and neurocognitive function after single doses of mitragynine in humans.Psychopharmacology · 2025Article
- Kratom's Use and Impact on Pediatric Populations.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025Article
- Kratom (Mitragyna speciosa) use for self-management of pain: Insights from cross-sectional and ecological momentary assessment data.The journal of pain · 2025Article
- Dual anti-inflammatory activities of COX-2/5-LOX driven by kratom alkaloid extracts in lipopolysaccharide-induced RAW 264.7 cells.Scientific reports · 2024Article
- [Kratom-From natural remedy to addictive drug and back].Der Nervenarzt · 2024Review
- Controversies in Assessment, Diagnosis, and Treatment of Kratom Use Disorder.Current psychiatry reports · 2024Review
- Multiple-Dose Pharmacokinetics and Safety of Mitragynine, the Major Alkaloid of Kratom, in Rats.ACS pharmacology & translational science · 2024Article
- Effects of Itraconazole on Pharmacokinetics of Mitragynine and 7-Hydroxymitragynine in Healthy Volunteers.ACS pharmacology & translational science · 2024Article
- Kratom safety and toxicology in the public health context: research needs to better inform regulation.Frontiers in pharmacology · 2024Review
- Translating Kratom-Drug Interactions: From Bedside to Bench and Back.Drug metabolism and disposition: the biological fate of chemicals · 2023Review
- An evaluation of adverse drug reactions and outcomes attributed to kratom in the US Food and Drug Administration Adverse Event Reporting System from January 2004 through September 2021.Clinical and translational science · 2023Article
- Kratom withdrawal: Discussions and conclusions of a scientific expert forum.Drug and alcohol dependence reports · 2023Article
- Clinical Implications of Kratom (Current addiction reports · 2023Review
- Social, psychological, and substance use characteristics of U.S. adults who use kratom: Initial findings from an online, crowdsourced study.Experimental and clinical psychopharmacology · 2022Article
- [Kratom - a short review for pain medicine].Schmerz (Berlin, Germany) · 2022Review
- How essential is kratom availability and use during COVID-19? Use pattern analysis based on survey and social media data.Substance abuse · 2022Article
- Searching for a Signal: Self-Reported Kratom Dose-Effect Relationships Among a Sample of US Adults With Regular Kratom Use Histories.Frontiers in pharmacology · 2022Article
- Understanding Kratom Use: A Guide for Healthcare Providers.Frontiers in pharmacology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
32607084PMC7309661What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.