ArticleCancer management and research2020
Intercalary Allograft to Reconstruct Large-Segment Diaphysis Defects After Resection of Lower Extremity Malignant Bone Tumor.
Article in Cancer management and research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Advances in Surgical Management of Malignant Tumors of the Distal Tibia.Current treatment options in oncology · 2025Review
- Surgical mechanical properties of perfused decellularized massive bone allografts: An comparative in vivo test.PloS one · 2025Article
- Is intercalary frozen autograft augmented with intramedullary cement and bridging plates fixation a durable reconstruction?Journal of orthopaedic surgery and research · 2024Article
- Allografts use in orthopedic surgery: trend change over the past 11 years from a regional tissue bank.Cell and tissue banking · 2024Article
- Clinical application of LARS tumor tube in joint function reconstruction of tumor type artificial hip replacement.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Article
- 3D-Printed Personalized Lattice Implant as an Innovative Strategy to Reconstruct Geographic Defects in Load-Bearing Bones.Orthopaedic surgery · 2024Article
- Intercalary Prosthetic Reconstruction with Three-Dimensional-Printed Custom-Made Porous Component for Defects of Long Bones with Short Residual Bone Segments After Tumor Resection.Orthopaedic surgery · 2024Article
- Evaluation of Absolute Neutrophil Count in the Perioperative Setting of Sarcoma Resection.Advances in orthopedics · 2024Article
- Biological reconstruction of bone defect after resection of malignant bone tumor by allograft: a single-center retrospective cohort study.World journal of surgical oncology · 2023Article
- Customized three dimensional printed prosthesis as a novel intercalary reconstruction for resection of extremity bone tumours: a retrospective cohort study.International orthopaedics · 2022Article
- Intercalary frozen autografts for reconstruction of bone defects following meta-/diaphyseal tumor resection at the extremities.BMC musculoskeletal disorders · 2022Review
- Allograft versus autograft for reconstruction after resection of primary bone tumors: a comparative study of long-term clinical outcomes and risk factors for failure of reconstruction.Scientific reports · 2022Article
- Intercalary reconstruction of long bones by massive allograft: Comparison of construct stability ensured by three different host-graft junctions and two types of fixations in a synthetic femur model.Frontiers in pediatrics · 2022Article
- Preliminary Results of the "Capasquelet" Technique for Managing Femoral Bone Defects-Combining a Masquelet Induced Membrane and Capanna Vascularized Fibula with an Allograft.Journal of personalized medicine · 2021Article
- Concave-convex Reaming of Intercalary Allograft: 1-year Clinical Outcomes.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2021Article
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the clinical effect of intercalary allograft transplantation and reconstruction in the treatment of diaphyseal defect after resection of lower extremity malignant bone tumor.
methodsClinical data of 17 patients diagnosed with malignant lower-limb bone tumors and having undergone segmental allograft reconstruction with a mean follow-up of 49.8 (26-78) months were included. Segmental allografts of average 17-cm length preserved by deep-freezing were used and fixed using intramedullary nail, double plate, and intramedullary nail and plate combination in 2, 5, and 10 patients, respectively. Host-donor junctions were perfectly and roughly matched in 5 and 12 patients, respectively. Allograft union, local recurrence, and complications were assessed using clinical and radiological tests. Allograft union was evaluated using the International Society of Limb Salvage (ISOLS) scoring system. The functional prognosis was evaluated using the Musculoskeletal Tumour Society (MSTS) scoring system.
resultsIntercalary allograft reconstruction of femoral shaft, tibial shaft, and distal tibia with ankle arthrodesis was performed in eight, four, and five patients, respectively. Two patients had local recurrence and underwent amputation; one died of metastasis. Host-donor junctions in two patients showed nonunion; 12 patients achieved bone union. The average union time was 12.1 months. No allograft fracture or infection occurred. Union rates were 100% and 88.2% at metaphyseal and diaphyseal junctions, respectively. Healing time differed significantly between the precisely and roughly matched groups (p<0.01). The incidence of nonunion was higher after intramedullary nailing than after the other two methods (p<0.05). The mean MSTS score was 24.2 (14-29) at the end of follow-up.
conclusionIntercalary allograft transplantation is an effective strategy for diaphyseal defect following post-tumor resection in the lower extremity. Good bone healing after allograft reconstruction is achieved with stable internal fixation and perfectly matched host-donor interfaces.
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