Evidence map›Paper›PMID 32606692›Full record

ArticleInternational journal of nanomedicine2020

Selenium Nanoparticles Synthesized Using

Karthik Rajkumar, Sandhya Mvs, Siva Koganti, Sandeepta Burgula

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 62 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Karthik RajkumarDepartment of Microbiology, Osmania University, Tarnaka, Hyderabad 500007, India.ORCID 0000-0002-3604-3657
Sandhya MvsDepartment of Microbiology, Osmania University, Tarnaka, Hyderabad 500007, India.
Siva KogantiCenter for Advanced Research, Sri Venkateswara Institute of Medical Sciences, Tirupati 517507, India.
Sandeepta BurgulaDepartment of Microbiology, Osmania University, Tarnaka, Hyderabad 500007, India.ORCID 0000-0002-4691-6570
Osmania University · INSri Venkateswara Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSelenium nanoparticles (SeNP) have several applications in the field of biotechnology, including their use as anti-cancer drugs. The purpose of the present study is to analyze the efficacy of green synthesis on the preparation of SeNP and its effect on their anti-cancer properties.

methodsA bacterial strain isolated from a freshwater source was shown to efficiently synthesize SeNP with potential therapeutic properties. The quality and stability of the NP were studied by scanning electron microscopy, X-ray diffraction, zeta-potential and FTIR analysis. A cost-effective medium formulation from biowaste having 6% banana peel extract enriched with 0.25 mM tryptophan was used to synthesize the NP. The NP after optimization was used to analyze their anti-tumor and anti-angiogenic activity. For this purpose, first, the cytotoxicity of the NP against cancer cells was analyzed by MTT assay and then chorioallantoic membrane assay was performed to assess anti-angiogenic activity. Further, cell migration assay and clonogenic inhibition assay were performed to test the anti-tumor properties of SeNP. To assess the cytotoxicity of SeNP on healthy RBC, hemolysis assay was performed.

resultsThe strain identified as

conclusion

Indexed as

Angiogenesis InhibitorsAnimalsAntineoplastic AgentsCell DeathCell MovementCell ProliferationCell SurvivalChick EmbryoCosts and Cost AnalysisFemaleHeLa CellsHemolysisHumansMetal NanoparticlesPhenazinesPseudomonas stutzeri1-phenazinecarboxylic acidAngiogenesis InhibitorsAntineoplastic AgentsPhenazinesSeleniumanti-angiogenic activitycell migrationcervical cancer cellsclonal proliferationMH191156Pseudomonas stutzeriselenium nanoparticles

Identifiers

PMID32606692
PMCPMC7320886
OpenAlexW3036892965

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.