ArticleInternational journal of nanomedicine2020
Chitosan Coating of TiO2 Nanotube Arrays for Improved Metformin Release and Osteoblast Differentiation.
Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- Grain Size and Electrochemical Surface Modification Effects on Corrosion, Biological, and Technological Properties of CP Titanium Implants.Journal of functional biomaterials · 2025Article
- How TiOInternational journal of nanomedicine · 2025Review
- Extracellular Vesicles and Hydrogels: An Innovative Approach to Tissue Regeneration.ACS omega · 2024Review
- Bisphosphonate-incorporated coatings for orthopedic implants functionalization.Materials today. Bio · 2023Review
- Effects of metformin on the bioactivity and osseointegration of dental implants: A systematic review.Journal of Taibah University Medical Sciences · 2023Review
- Chitosan nanoparticles for sustained release of metformin and its derived synthetic biopolymer for bone regeneration.Frontiers in bioengineering and biotechnology · 2023Article
- Antibacterial Ti-Cu implants: A critical review on mechanisms of action.Materials today. Bio · 2022Review
- Synthesis, Characterization, and Antimicrobial and Antiproliferative Effects of CuO-TiONanomaterials (Basel, Switzerland) · 2022Article
- Ciprofloxacin-Loaded Titanium Nanotubes Coated with Chitosan: A Promising Formulation with Sustained Release and Enhanced Antibacterial Properties.Pharmaceutics · 2022Article
- Applications of Titanium Dioxide Nanostructure in Stomatology.Molecules (Basel, Switzerland) · 2022Review
- A two-phase and long-lasting multi-antibacterial coating enables titanium biomaterials to prevent implants-related infections.Materials today. Bio · 2022Article
- Advanced Surface Modification for 3D-Printed Titanium Alloy Implant Interface Functionalization.Frontiers in bioengineering and biotechnology · 2022Review
- Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants.Biomedicines · 2021Review
- Anodic TiONanomaterials (Basel, Switzerland) · 2021Review
- Regulation of Stem Cell Differentiation by Inorganic Nanomaterials: Recent Advances in Regenerative Medicine.Frontiers in bioengineering and biotechnology · 2021Review
- Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications.Molecules (Basel, Switzerland) · 2020Review
- Impedimetric Detection of Femtomolar Levels of Interleukin6, Interleukin 8, and Tumor Necrosis Factor Alpha Based on Thermally Modified Nanotubular Titanium Dioxide Arrays.Nanomaterials (Basel, Switzerland) · 2020Article
- In Vitro and In Vivo Biocompatibility Studies of a Cast and Coated Titanium Alloy.Molecules (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIneffective integration has been recognized as one of the major causes of early orthopedic failure of titanium-based implants. One strategy to address this problem is to develop modified titanium surfaces that promote osteoblast differentiation. This study explored titanium surfaces modified with TiO2 nanotubes (TiO2 NTs) capable of localized drug delivery into bone and enhanced osteoblast cell differentiation. MATERIALS AND
methodsBriefly, TiO2 NTs were subjected to anodic oxidation and loaded with Metformin, a widely used diabetes drug. To create surfaces with sustainable drug-eluting characteristics, TiO2 NTs were spin coated with a thin layer of chitosan. The surfaces were characterized via scanning electron microscopy, atomic force microscopy, and contact angle measurements. The surfaces were then exposed to mesenchymal bone marrow stem cells (MSCs) to evaluate cell adhesion, growth, differentiation, and morphology on the modified surfaces.
resultsA noticeable increase in drug release time (3 days vs 20 days) and a decrease in burst release characteristics (85% to 7%) was observed in coated samples as compared to uncoated samples, respectively. Chitosan-coated TiO2 NTs exhibited a considerable enhancement in cell adhesion, proliferation, and genetic expression of type I collagen, and alkaline phosphatase activity as compared to uncoated TiO2 NTs.
conclusionTiO2 NT surfaces with a chitosan coating are capable of delivering Metformin to a bone site over a sustained period of time with the potential to enhance MSCs cell attachment, proliferation, and differentiation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.