Evidence map›Paper›PMID 32606677›Full record

ArticleInternational journal of nanomedicine2020

Enhanced Antibacterial Activity of Se Nanoparticles Upon Coating with Recombinant Spider Silk Protein eADF4(κ16).

Tao Huang, Sushma Kumari, Heike Herold, Hendrik Bargel, Tamara B Aigner, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor, Thomas Scheibel

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Tao HuangDepartment of Biomedical Engineering, Melbourne School of Engineering, University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0001-6280-0693
Sushma KumariDepartment for Biomaterials, Faculty of Engineering Science, University of Bayreuth, Prof. Rüdiger Bormann Str. 1, Bayreuth 95447, Germany.ORCID 0000-0003-4042-2294
Heike HeroldDepartment for Biomaterials, Faculty of Engineering Science, University of Bayreuth, Prof. Rüdiger Bormann Str. 1, Bayreuth 95447, Germany.ORCID 0000-0002-9934-2590
Hendrik BargelDepartment for Biomaterials, Faculty of Engineering Science, University of Bayreuth, Prof. Rüdiger Bormann Str. 1, Bayreuth 95447, Germany.ORCID 0000-0001-5682-2220
Tamara B AignerDepartment for Biomaterials, Faculty of Engineering Science, University of Bayreuth, Prof. Rüdiger Bormann Str. 1, Bayreuth 95447, Germany.
Daniel E HeathDepartment of Biomedical Engineering, Melbourne School of Engineering, University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0003-3171-886X
Neil M O'Brien-SimpsonMelbourne Dental School and the Bio21 Institute of Molecular Science and Biotechnology, The University of Melbourne, Parkville, VIC 3010, Australia.
Andrea J O'ConnorDepartment of Biomedical Engineering, Melbourne School of Engineering, University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0001-6925-885X
Thomas ScheibelDepartment for Biomaterials, Faculty of Engineering Science, University of Bayreuth, Prof. Rüdiger Bormann Str. 1, Bayreuth 95447, Germany.ORCID 0000-0002-0457-2423
The University of Melbourne · AUUniversity of Bayreuth · DEBavarian Polymer Institute · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSelenium nanoparticles (Se NPs) are promising antibacterial agents to tackle the growing problem of antimicrobial resistance. The aim of this study was to fabricate Se NPs with a net positive charge to enhance their antibacterial efficacy.

methodsSe NPs were coated with a positively charged protein - recombinant spider silk protein eADF4(κ16) - to give them a net positive surface charge. Their cytotoxicity and antibacterial activity were investigated, with negatively charged polyvinyl alcohol coated Se NPs as a control. Besides, these eADF4(κ16)-coated Se NPs were immobilized on the spider silk films, and the antibacterial activity of these films was investigated.

resultsCompared to the negatively charged polyvinyl alcohol coated Se NPs, the positively charged eADF4(κ16)-coated Se NPs demonstrated a much higher bactericidal efficacy against the Gram-negative bacteria

conclusionOverall, eADF4(κ16)-coated Se NPs are promising new antibacterial agents against life-threatening bacteria.

Indexed as

3T3 CellsAnimalsAnti-Bacterial AgentsCell DeathCell SurvivalColony Count, MicrobialEscherichia coliFibroblastsHumansKeratinocytesMiceMice, Inbred BALB CMicrobial Sensitivity TestsNanoparticlesParticle SizeRecombinant ProteinsAnti-Bacterial AgentsRecombinant ProteinsSeleniumSilkantibacterial filmcytotoxicityE. coliGram-negativeGram-positive

Identifiers

PMID32606677
PMCPMC7306472
OpenAlexW3035725662

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.