Evidence map›Paper›PMID 32606645›Full record

Observational studyInternational journal of chronic obstructive pulmonary disease2020

Detection of Cell-Dissociated Non-Typeable

Samantha J Thulborn, Alessandro Ceroni, Koirobi Haldar, Vijay Mistry, Jennifer L Cane, Christopher E Brightling, Michael R Barer, Mona Bafadhel

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of chronic obstructive pulmonary disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Samantha J ThulbornRespiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Alessandro CeroniTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Koirobi HaldarDepartment of Immunity, Infection and Inflammation, University of Leicester, Leicester, UK.
Vijay MistryDepartment of Immunity, Infection and Inflammation, University of Leicester, Leicester, UK.
Jennifer L CaneRespiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Christopher E BrightlingDepartment of Immunity, Infection and Inflammation, University of Leicester, Leicester, UK.
Michael R BarerDepartment of Immunity, Infection and Inflammation, University of Leicester, Leicester, UK.
Mona BafadhelRespiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-9993-2478
University of Leicester · GBUniversity of Oxford · GB

Funding

Medical Research Council G0601369
6 · The paper itself

Abstract

Background: Non-typeable Methods: DNA was extracted from the sputum plug and cell-free supernatant to quantify absolute (cell-associated and cell-dissociated NTHi) and cell-dissociated NTHi, respectively, from 87 COPD subjects attending an observational longitudinal COPD exacerbation study. NTHi was quantified using TaqMan hydrolysis probes, targeting the OMP P6 gene using qPCR. Results: At stable state cell-dissociated NTHi was detected 56% of subjects with a median (IQR) of 9.95x10 Conclusion: In patients with COPD, NTHi can exist in both cell-associated and cell-dissociated forms. Cell-dissociated NTHi is associated with neutrophilic airway inflammation during exacerbations of COPD and may be a driving factor in worsening lung function during these episodes.

Indexed as

Haemophilus InfectionsPulmonary Disease, Chronic ObstructiveHaemophilus influenzaeHumansSeverity of Illness IndexSputumCOPDinfectionneutrophilsNTHi

Identifiers

PMID32606645
PMCPMC7297347
OpenAlexW3035146106

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.