Evidence map›Paper›PMID 32606613›Full record

ArticlePatient preference and adherence2020

Treatment Mode Preferences in Psoriatic Arthritis: A Qualitative Multi-Country Study.

Daniel Aletaha, M Elaine Husni, Joseph F Merola, Roberto Ranza, Heidi Bertheussen, Ralph Lippe, Pamela M Young, Joseph C Cappelleri, T Michelle Brown, Claire Ervin and 2 more

Abstract read
In one paragraph

Article in Patient preference and adherence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Daniel AletahaDivision of Rheumatology, Department of Internal Medicine 3, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-2108-0030
M Elaine HusniCleveland Clinic, Department of Rheumatic and Immunologic Diseases, Cleveland, OH, USA.ORCID 0000-0002-3181-4205
Joseph F MerolaBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Roberto RanzaServiço de Reumatología, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, Brazil.
Heidi BertheussenPatient Representative, Oslo, Norway.ORCID 0000-0001-6693-9254
Ralph LippeInflammation & Immunology, Pfizer Pharma GmbH, Berlin, Germany.
Pamela M YoungInflammation & Immunology, Pfizer Inc, Collegeville, PA, USA.
Joseph C CappelleriStatistics, Pfizer Inc, Groton, CT, USA.ORCID 0000-0001-9586-0748
T Michelle BrownRTI Health Solutions, Research Triangle Park, NC, USA.
Claire ErvinRTI Health Solutions, Research Triangle Park, NC, USA.
Ming-Ann HsuHealth Economics & Outcomes Research, Pfizer Inc, Groton, CT, USA.
Lara FallonMedical Affairs, Pfizer Inc, Montreal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveQualitative research exploring patient preferences regarding the mode of treatment administration for psoriatic arthritis (PsA) is limited. We report patient preferences and their reasons across PsA treatment modes.

methodsIn this global, cross-sectional, qualitative study, interviews were conducted with adult patients with PsA in Brazil, France, Germany, Italy, Spain, the UK, and the US. Patients were currently taking a disease-modifying antirheumatic drug (DMARD). Patients indicated the order and strength of preference (0-100; 100 = strongest) across four modes of treatment administration: oral (once daily), self-injection (weekly), clinic injection (weekly), and infusion (monthly); reasons for preferences were qualitatively assessed. Descriptive statistics were reported. Fisher's exact tests and

resultsOverall, 85 patients were interviewed (female, 60.0%; mean age, 49.8 years). First-choice ranking (%) and mean [standard deviation] preference points were: oral (49.4%; 43.9 [31.9]); self-injection (34.1%; 32.4 [24.8]); infusion (15.3%; 14.5 [20.0]); clinic injection (1.2%; 9.2 [10.0]). Of 48 (56.5%) patients with a strong first-choice preference (ie point allocation ≥60), 66.7% chose oral administration. Self-injection was most often selected as second choice (51.8%), clinic injection as third (49.4%), and infusion as fourth (47.1%). Oral administration was the first-choice preference in the US (88.0% vs 38.0% in Europe). The most commonly reported reason for oral administration as the first choice was speed and ease of administration (76.2%); for self-injection, this was convenience (75.9%). The most commonly reported reason for avoiding oral administration was concern about possible drug interactions (63.6%); for self-injection, this was a dislike of needles or the injection process (66.7%).

conclusionPatients with PsA preferred oral treatment administration, followed by self-injection; convenience factors were common reasons for these preferences. Overall, 43.5% of patients did not feel strongly about their first-choice preference and may benefit from discussions with healthcare professionals about PsA treatment administration options.

Indexed as

patient preferencepsoriatic arthritisqualitative researchtreatment administration

Identifiers

PMID32606613
PMCPMC7293411

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.