Evidence map›Paper›PMID 32606589›Full record

ArticleDrug design, development and therapy2020

Comparative Cholinesterase, α-Glucosidase Inhibitory, Antioxidant, Molecular Docking, and Kinetic Studies on Potent Succinimide Derivatives.

Ashfaq Ahmad, Farhat Ullah, Abdul Sadiq, Muhammad Ayaz, Muhammad Saeed Jan, Muhammad Shahid, Abdul Wadood, Fawad Mahmood, Umer Rashid, Riaz Ullah and 3 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Drug design, development and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Assessment of the Biological Properties ofMolecules (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Succinimide Derivatives as Antioxidant Anticholinesterases, Anti-Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  13. Article
  14. GC-MS Analysis and Various In Vitro and In Vivo Pharmacological Potential ofEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  15. Synthesis, Antioxidant, and Antidiabetic Activities of Ketone Derivatives of Succinimide.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Ashfaq AhmadDepartment of Pharmacy, Sarhad University of Science & Technology, Peshawar, KPK, Pakistan.
Farhat UllahDepartment of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara, 18000, KP, Pakistan.
Abdul SadiqDepartment of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara, 18000, KP, Pakistan.
Muhammad AyazDepartment of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara, 18000, KP, Pakistan.ORCID 0000-0002-4299-2445
Muhammad Saeed JanDepartment of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara, 18000, KP, Pakistan.ORCID 0000-0003-2411-6510
Muhammad ShahidDepartment of Pharmacy, Sarhad University of Science & Technology, Peshawar, KPK, Pakistan.ORCID 0000-0002-6953-7848
Abdul WadoodDepartment of Biochemistry, UCS, Shankar Abdul Wali Khan University, Mardan 23200, Pakistan.
Fawad MahmoodDepartment of Pharmacy, Sarhad University of Science & Technology, Peshawar, KPK, Pakistan.
Umer RashidDepartment of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.
Riaz UllahDepartment of Pharmacognosy, Medicinal, Aromatic and Poisonous Plants Research Center (MAPRC), College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.
Muhammad Umar Khayam SahibzadaDepartment of Pharmacy, Sarhad University of Science & Technology, Peshawar, KPK, Pakistan.ORCID 0000-0002-9768-4255
Ali S AlqahtaniDepartment of Pharmacognosy, Medicinal, Aromatic and Poisonous Plants Research Center (MAPRC), College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.
Hafiz Majid MahmoodDepartment of Pharmacology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-9215-0505
Sarhad University of Science and Information Technology · PKUniversity of Malakand · PKKing Saud University · SAAbdul Wali Khan University Mardan · PKCOMSATS University Islamabad · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe current study was designed to synthesize derivatives of succinimide and compare their biological potency in anticholinesterase, alpha-glucosidase inhibition, and antioxidant assays.

methodsIn this research, two succinimide derivatives including (

resultsIn AChE inhibitory assay, compounds

conclusionBoth succinimide derivatives exhibited considerable inhibitory activities against cholinesterases and α-glucosidase enzymes. Of these two, compound

Indexed as

Molecular Docking Simulationalpha-GlucosidasesAnimalsAntioxidantsBenzothiazolesBiphenyl CompoundsCholinesterase InhibitorsCholinesterasesElectrophorusGlycoside Hydrolase InhibitorsHorsesHumansKineticsMolecular StructurePicratesSuccinimides1,1-diphenyl-2-picrylhydrazyl2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acidalpha-GlucosidasesAntioxidantsBenzothiazolesBiphenyl CompoundsCholinesterase InhibitorsCholinesterasesGlycoside Hydrolase InhibitorsPicratessuccinimideSuccinimidesSulfonic AcidsAlzheimer’s diseaseantioxidantcholinesteraseglucosidasemolecular dockingsuccinimides

Identifiers

PMID32606589
PMCPMC7285812
OpenAlexW3033317366

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.