Evidence map›Paper›PMID 32606384›Full record

ArticleScientific reports2020

Combined and independent effects of hypoxia and tributyltin on mRNA expression and physiology of the Eastern oyster (Crassostrea virginica).

Ann Fairly Barnett, James H Gledhill, Robert J Griffitt, Marc Slattery, Deborah J Gochfeld, Kristine L Willett

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ann Fairly Barnett *Division of Environmental Toxicology, Department of BioMolecular Sciences, University of Mississippi, P.O. Box 1848, University, MS, 38677, USA.
James H Gledhill *Division of Environmental Toxicology, Department of BioMolecular Sciences, University of Mississippi, P.O. Box 1848, University, MS, 38677, USA.
Robert J GriffittSchool of Ocean Science and Engineering, University of Southern Mississippi, 703 East Beach Road, Ocean Springs, MS, 39564, USA.
Marc SlatteryDivision of Environmental Toxicology, Department of BioMolecular Sciences, University of Mississippi, P.O. Box 1848, University, MS, 38677, USA.
Deborah J GochfeldDivision of Environmental Toxicology, Department of BioMolecular Sciences, University of Mississippi, P.O. Box 1848, University, MS, 38677, USA.
Kristine L WillettDivision of Environmental Toxicology, Department of BioMolecular Sciences, University of Mississippi, P.O. Box 1848, University, MS, 38677, USA. kwillett@olemiss.edu.
University of Mississippi · USUniversity of Southern Mississippi · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oyster reefs are vital to estuarine health, but they experience multiple stressors and globally declining populations. This study examined effects of hypoxia and tributyltin (TBT) on adult Eastern oysters (Crassostrea virginica) exposed either in the laboratory or the field following a natural hypoxic event. In the laboratory, oysters were exposed to either hypoxia followed by a recovery period, or to hypoxia combined with TBT. mRNA expression of HIF1-α and Tβ-4 along with hemocyte counts, biomarkers of hypoxic stress and immune health, respectively, were measured. In field-deployed oysters, HIF1-α and Tβ-4 expression increased, while no effect on hemocytes was observed. In contrast, after 6 and 8 days of laboratory-based hypoxia exposure, both Tβ-4 expression and hemocyte counts declined. After 8 days of exposure to hypoxia + TBT, oysters substantially up-regulated HIF1-α and down-regulated Tβ-4, although hemocyte counts were unaffected. Results suggest that hypoxic exposure induces immunosuppression which could increase vulnerability to pathogens.

Indexed as

CrassostreaAnimalsGene ExpressionHemocytesHypoxiaHypoxia-Inducible Factor 1, alpha SubunitRNA, MessengerTrialkyltin CompoundsHypoxia-Inducible Factor 1, alpha SubunitRNA, MessengerTrialkyltin Compoundstributyltin

Identifiers

PMID32606384
PMCPMC7327041
OpenAlexW3038223840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.