Evidence map›Paper›PMID 32606377›Full record

ArticleMolecular psychiatry2021

Genome-wide mapping of brain phenotypes in extended pedigrees with strong genetic loading for bipolar disorder.

Scott C Fears, Susan K Service, Barbara Kremeyer, Carmen Araya, Xinia Araya, Julio Bejarano, Margarita Ramirez, Gabriel Castrillón, Juliana Gomez-Franco, Maria C Lopez and 17 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 10 institutions in 6 countries.

Scott C FearsDepartment of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA. sfears@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-6443-2318
Susan K ServiceDepartment of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.
Barbara KremeyerDepartment of Genetics, Evolution and Environment, University College London, London, WC1E 6BT, UK.
Carmen ArayaCell and Molecular Biology Research Center, Universidad de Costa Rica, San Pedro de Montes de Oca, Costa Rica.
Xinia ArayaCell and Molecular Biology Research Center, Universidad de Costa Rica, San Pedro de Montes de Oca, Costa Rica.
Julio BejaranoCell and Molecular Biology Research Center, Universidad de Costa Rica, San Pedro de Montes de Oca, Costa Rica.
Margarita RamirezCell and Molecular Biology Research Center, Universidad de Costa Rica, San Pedro de Montes de Oca, Costa Rica.
Gabriel CastrillónInsituto de Alta Tecnologìa Mèdica, Medellín, Colombia.
Juliana Gomez-FrancoDepartment of Psychiatry, Harbor-UCLA Hospital, Los Angeles, CA, USA.
Maria C LopezGrupo de Investigación en Psiquiatría (Research Group in Psychiatry (GIPSI)), Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Gabriel MontoyaGrupo de Investigación en Psiquiatría (Research Group in Psychiatry (GIPSI)), Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Patricia MontoyaGrupo de Investigación en Psiquiatría (Research Group in Psychiatry (GIPSI)), Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Ileana AldanaDepartment of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.
Terri M TeshibaDepartment of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.
Noor B Al-SharifDepartment of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.
Maria JalbrzikowskiDepartment of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.
Todd A TishlerDepartment of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.
Javier EscobarDepartment of Psychiatry and Family Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
Andrés Ruiz-LinaresMinistry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Yangpu District, Shanghai, China.
Carlos Lopez-JaramilloGrupo de Investigación en Psiquiatría (Research Group in Psychiatry (GIPSI)), Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Gabriel MacayaCell and Molecular Biology Research Center, Universidad de Costa Rica, San Pedro de Montes de Oca, Costa Rica.ORCID http://orcid.org/0000-0001-5264-8691
Julio MolinaDepartment of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.
Victor I ReusDepartment of Psychiatry, University of California, San Francisco, CA, USA.
Rita M CantorDepartment of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.
Chiara SabattiDepartment of Health Research and Policy, Stanford University, Stanford, CA, USA.
Nelson B FreimerDepartment of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-3586-6587
Carrie E BeardenDepartment of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8516-923X
University of California, Los Angeles · USUniversidad de Costa Rica · CRUniversidad de Antioquia · COCentre National de la Recherche Scientifique · FRRutgers, The State University of New Jersey · USStanford University · USUCLA Medical Center · USUniversity College London · GBUniversity of California, San Francisco · USWest Los Angeles College · US

Funding

Integrative Center for Neurogenetics and Neurogenomics - OverallP30NS062691 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ESKIN, ELEAZAR · 2009 to 2018
$7.4M
Bipolar Endophenotypes in Population IsolatesR01MH075007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B. · 2007 to 2011
$3.8M
Genome Sequencing in Extended Bipolar PedigreesR01MH095454 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B. · 2012 to 2014
$2.4M
New Statistical Methods for High Resolution Mapping of Multiple PhenotypesR01HG006695 · NHGRI · STANFORD UNIVERSITY · PI SABATTI, CHIARA · 2013 to 2015
$1.0M
Quantitative Genetic Analyisis of Brain Structural PhenotypesK08MH086786 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEARS, SCOTT C. · 2009 to 2013
$925k
Identification of endophenotypes for bipolar disorderK23MH074644 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E · 2005 to 2009
$808k
NHGRI NIH HHS R01 HG006695NIMH NIH HHS K08 MH086786NIMH NIH HHS K23 MH074644NIMH NIH HHS R01 MH075007NIMH NIH HHS R01 MH095454NINDS NIH HHS P30 NS062691
6 · The paper itself

Abstract

Bipolar disorder is a highly heritable illness, associated with alterations of brain structure. As such, identification of genes influencing inter-individual differences in brain morphology may help elucidate the underlying pathophysiology of bipolar disorder (BP). To identify quantitative trait loci (QTL) that contribute to phenotypic variance of brain structure, structural neuroimages were acquired from family members (n = 527) of extended pedigrees heavily loaded for bipolar disorder ascertained from genetically isolated populations in Latin America. Genome-wide linkage and association analysis were conducted on the subset of heritable brain traits that showed significant evidence of association with bipolar disorder (n = 24) to map QTL influencing regional measures of brain volume and cortical thickness. Two chromosomal regions showed significant evidence of linkage; a QTL on chromosome 1p influencing corpus callosum volume and a region on chromosome 7p linked to cortical volume. Association analysis within the two QTLs identified three SNPs correlated with the brain measures.

Indexed as

Bipolar DisorderBrainGenetic LinkageHumansPedigreePhenotypeQuantitative Trait Loci

Identifiers

PMID32606377
OpenAlexW3039066561

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.