ArticleScientific reports2020
Changes in cross-frequency coupling following closed-loop auditory stimulation in non-rapid eye movement sleep.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The effect of zolpidem on targeted memory reactivation during sleep.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Trial
- A Wearable Brain-Computer Interface for Mitigating Car Sickness via Attention Shifting.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Future of Non-Invasive Brain Stimulation in Sleep Medicine.Journal of sleep research · 2025Review
- Personalized targeted memory reactivation enhances consolidation of challenging memories via slow wave and spindle dynamics.NPJ science of learning · 2025Article
- Overnight changes in performance fatigability and their relationship to modulated deep sleep oscillations via auditory stimulation.Journal of sleep research · 2025Article
- Optimizing automated phase-targeted auditory stimulation protocols for procedural memory consolidation during sleep in a home setting.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Acoustically evoked K-complexes together with sleep spindles boost verbal declarative memory consolidation in healthy adults.Scientific reports · 2024Article
- Neural reactivation during human sleep.Emerging topics in life sciences · 2023Review
- Cross-Frequency Coupling and Intelligent Neuromodulation.Cyborg and bionic systems (Washington, D.C.) · 2023Review
- Alterations in TRN-anterodorsal thalamocortical circuits affect sleep architecture and homeostatic processes in oxidative stress vulnerable GclmMolecular psychiatry · 2022Article
- Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats.eLife · 2021Article
- Sounding It Out: Auditory Stimulation and Overnight Memory Processing.Current sleep medicine reports · 2021Review
- Neuromodulation of sleep rhythms in schizophrenia: Towards the rational design of non-invasive brain stimulation.Schizophrenia research · 2020Review
- Effectiveness of Visual vs. Acoustic Closed-Loop Stimulation on EEG Power Density during NREM Sleep in Humans.Clocks & sleep · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regional changes of non-rapid eye movement (NREM) sleep delta and sigma activity, and their temporal coupling have been related to experience-dependent plastic changes during previous wakefulness. These sleep-specific rhythms seem to be important for brain recovery and memory consolidation. Recently, it was demonstrated that by targeting slow waves in a particular region at a specific phase with closed-loop auditory stimulation, it is possible to locally manipulate slow-wave activity and interact with training-induced neuroplastic changes. In our study, we tested whether closed-loop auditory stimulation targeting the up-phase of slow waves might not only interact with the main sleep rhythms but also with their coupling within the circumscribed region. We demonstrate that while closed-loop auditory stimulation globally enhances delta, theta and sigma power, changes in cross-frequency coupling of these oscillations were more spatially restricted. Importantly, a significant increase in delta-sigma coupling was observed over the right parietal area, located directly posterior to the target electrode. These findings suggest that closed-loop auditory stimulation locally modulates coupling between delta phase and sigma power in a targeted region, which could be used to manipulate sleep-dependent neuroplasticity within the brain network of interest.
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