Evidence map›Paper›PMID 32606142›Full record

ArticleIn vivo (Athens, Greece)

Association of Leukocyte Telomere Length and Genes Involved in its Regulation With Oral Carcinoma.

Zaneta Jumatovaite, Albertas Kriauciunas, Alvita Vilkeviciute, Greta Gedvilaite, Vykintas Liutkevicius, Virgilijus Uloza, Alina Smalinskiene, Rasa Liutkeviciene

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zaneta JumatovaiteMedical Faculty, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Albertas KriauciunasDepartment of Prosthodontics, Lithuanian University of Health Sciences, Kaunas, Lithuania albertas.kriauciunas@lsmuni.lt.
Alvita VilkeviciuteNeuroscience Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Greta GedvilaiteNeuroscience Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Vykintas LiutkeviciusDepartment of Otorhinolaryngology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Virgilijus UlozaDepartment of Otorhinolaryngology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Alina SmalinskieneInstitute of Biological Systems and Genetics Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Rasa LiutkevicieneNeuroscience Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Lithuanian University of Health Sciences · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThis study aimed to determine the relationship between the relative leukocyte telomere length (RLTL) and gene polymorphisms involved in its regulation with the occurrence of oral squamous cell carcinoma (OSCC). PATIENTS AND

methodsPatients with OSCC and healthy subjects were examined. Genotyping and RLTL measurement were carried out using rPCR.

resultsThe OSCC group had longer telomeres than controls (p=0.001). Minor allele T at TERF1rs1545827 may increase RLTL shortening (p=0.047). TNKS2rs10509639 A/G and A/G+G/G genotypes were associated with a 2.6-fold increased odd (p=0.012) and a 2.4-fold increased odd (p=0.019) of RLTL elongation compared to A/A genotype. The A/G genotype was associated with a 2.6-fold increased odd (p=0.011) compared to the A/A+G/G genotypes. Each G allele was associated with a 2.1-fold increased odd of longer RLTL (p=0.036).

conclusionLonger telomeres were found in patients with OSCC than in controls. The TERF1 rs1545827 and the TNKS2 rs10509639 polymorphisms were associated with an increase in RLTL.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsMouth NeoplasmsTankyrasesGenetic Predisposition to DiseaseGenotypeHumansLeukocytesPolymorphism, Single NucleotideTelomereTankyrasesTNKS2 protein, humangene polymorphismsoral squamous cell carcinomaRelative leukocyte telomere length

Identifiers

PMID32606142
PMCPMC7439885
OpenAlexW3040679754

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.