Evidence map›Paper›PMID 32605990›Full record

ArticlemBio2020

Tornadic Shear Stress Induces a Transient, Calcineurin-Dependent Hypervirulent Phenotype in Mucorales Molds.

Sebastian Wurster, Alexander M Tatara, Nathaniel D Albert, Ashraf S Ibrahim, Joseph Heitman, Soo Chan Lee, Amol C Shetty, Carrie McCracken, Karen T Graf, Antonios G Mikos and 2 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Catheter mechanoprophylaxis againstMicrobiology (Reading, England) · 2026
    Article
  3. Article
  4. Review
  5. The Impact of Dimitrios P. Kontoyiannis on Mucormycosis Research.Journal of fungi (Basel, Switzerland) · 2024
    Article
  6. Molecular mechanisms that govern infection and antifungal resistance in Mucorales.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  7. AlternativeFrontiers in cellular and infection microbiology · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Fungal Priming: Prepare or Perish.Journal of fungi (Basel, Switzerland) · 2022
    Review
  13. Recent Advances and Future Directions in the Understanding of Mucormycosis.Frontiers in cellular and infection microbiology · 2022
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Sebastian WursterDepartment of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-7784-7256
Alexander M TataraDepartment of Bioengineering, Rice University, Houston, Texas, USA.
Nathaniel D AlbertDepartment of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
Ashraf S IbrahimLos Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Los Angeles, California, USA.
Joseph HeitmanDepartments of Molecular Genetics and Microbiology, Pharmacology and Cancer Biology, and Medicine, Duke University Medical Center, Durham, North Carolina, USA.ORCID 0000-0001-6369-5995
Soo Chan LeeSouth Texas Center of Emerging Infectious Diseases, Department of Biology, University of Texas at San Antonio, San Antonio, Texas, USA.
Amol C ShettyThe Institute for Genome Sciences, University of Maryland, Baltimore, Maryland, USA.
Carrie McCrackenThe Institute for Genome Sciences, University of Maryland, Baltimore, Maryland, USA.ORCID 0000-0002-8038-9727
Karen T GrafThe Institute for Genome Sciences, University of Maryland, Baltimore, Maryland, USA.
Antonios G MikosDepartment of Bioengineering, Rice University, Houston, Texas, USA.ORCID 0000-0002-0709-990X
Vincent M BrunoThe Institute for Genome Sciences, University of Maryland, Baltimore, Maryland, USA.ORCID 0000-0003-1683-2015
Dimitrios P KontoyiannisDepartment of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA dkontoyi@mdanderson.org.ORCID 0000-0002-8051-2940
University of Maryland, Baltimore · USThe University of Texas MD Anderson Cancer Center · USRice University · USDuke University · USThe Lundquist Institute · US

Funding

Technology CoreU19AI110820 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI WHITE, OWEN R · 2014 to 2023
$36.5M
Structure, function, and evolution of the Cryptococcus MAT locusR01AI050113 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2002 to 2024
$8.5M
Novel Toxins and Receptors in Mucormycosis Pathogenesis and TreatmentR01AI063503 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI IBRAHIM, ASHRAF S. · 2006 to 2025
$7.3M
ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITINGR01AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 1997 to 2025
$6.7M
Genetics of Cryptococcus sexual reproductionR37AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2011 to 2020
$4.9M
Therapeutic targeting of growth factor receptors to treat MucormycosisR01AI141360 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BRUNO, VINCENT MICHAEL · 2019 to 2023
$2.5M
NIAID NIH HHS R01 AI039115NIAID NIH HHS R01 AI050113NIAID NIH HHS R01 AI063503NIAID NIH HHS R01 AI141360NIAID NIH HHS R37 AI039115NIAID NIH HHS U19 AI110820
6 · The paper itself

Abstract

Trauma-related necrotizing myocutaneous mucormycosis (NMM) has a high morbidity and mortality in victims of combat-related injuries, geometeorological disasters, and severe burns. Inspired by the observation that several recent clusters of NMM have been associated with extreme mechanical forces (e.g., during tornados), we studied the impact of mechanical stress on Mucoralean biology and virulence in a

Indexed as

Stress, MechanicalA549 CellsAnimalsCalcineurinDrosophila melanogasterFemaleFusariumHumansMucoralesMucormycosisPhenotypeRhizopus oryzaeSpores, FungalVirulenceCalcineurinmechanobiologymucormycosisstress responsetraumavirulence

Identifiers

PMID32605990
PMCPMC7327176
OpenAlexW3038461232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.