ArticleThe Journal of biological chemistry2020
A polysaccharide extract from the medicinal plant Maidong inhibits the IKK-NF-κB pathway and IL-1β-induced islet inflammation and increases insulin secretion.
Registry-linked trialOpen access · hybridAbstract read
In one paragraph
Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06978023 (Clinical Safety, Efficacy and Multiomic Evaluation of a Novel Chinese Medicine Formula in Type 2 Diabetes), which is not on this map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT06978023 phase2not yet recruitingnot on this mapstarted 2025, after this paper: background citation
Clinical Safety, Efficacy and Multiomic Evaluation of a Novel Chinese Medicine Formula in Type 2 Diabetes: Effects on Beta-cell Function and Insulin Resistance
Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Targeted Regulation of Pancreatic Islet Function by Natural Products Against Type 2 Diabetes Mellitus: Advances and Prospects.Biomolecules · 2026Review
- Article
- Modified Huangqi Shengmai Yin enhances ruminal microbiome and metabolites activity in dairy cows with subclinical mastitis.Frontiers in veterinary science · 2025Article
- Therapeutic effects of Jing Si herbal tea for chronic obstructive pulmonary disease: a comprehensive investigation from clinical to basic research.Frontiers in pharmacology · 2025Article
- Advances in the study of Ophiopogon japonicus polysaccharides: structural characterization, bioactivity and gut microbiota modulation regulation.Frontiers in pharmacology · 2025Review
- Silencing the FABP3 gene in insulin-secreting cells reduces fatty acid uptake and protects against lipotoxicity.Acta diabetologica · 2024Article
- The Potential of Plant Polysaccharides and Chemotherapeutic Drug Combinations in the Suppression of Breast Cancer.International journal of molecular sciences · 2024Review
- Modulating the Gut Microbiota and Metabolites with Traditional Chinese Medicines: An Emerging Therapy for Type 2 Diabetes Mellitus and Its Complications.Molecules (Basel, Switzerland) · 2024Review
- Anti-diabetic effect of red quinoa polysaccharide on type 2 diabetic mellitus mice induced by streptozotocin and high-fat diet.Frontiers in microbiology · 2024Article
- Extraction, purification, structural characterization, bioactivities, modifications and structure-activity relationship of polysaccharides fromFrontiers in nutrition · 2024Review
- Jing Si Herbal Tea Modulates Macrophage Polarization and Inflammatory Signaling in LPS-Induced Inflammation.International journal of medical sciences · 2024Article
- A Chinese classical prescription Maimendong decoction in treatment of pulmonary fibrosis: an overview.Frontiers in pharmacology · 2024Review
- Classic mechanisms and experimental models for the anti-inflammatory effect of traditional Chinese medicine.Animal models and experimental medicine · 2022Review
- Identification of active compounds in Ophiopogonis Radix from different geographical origins by UPLC-Q/TOF-MS combined with GC-MS approaches.Open life sciences · 2022Article
- Natural Ingredients from Medicine Food Homology as Chemopreventive Reagents against Type 2 Diabetes Mellitus by Modulating Gut Microbiota Homoeostasis.Molecules (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 2 institutions in 4 countries.
Dandan MaoDepartment of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.
Xiao Yu TianSchool of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China.
Di MaoDepartment of Obstetrics and Gynaecology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.
Sze Wan HungDepartment of Obstetrics and Gynaecology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.ORCID 0000-0003-0576-4707
Chi Chiu WangDepartment of Obstetrics and Gynaecology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.ORCID 0000-0002-3928-7278
Clara Bik San LauInstitute of Chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0002-7409-1270
Heung Man LeeDepartment of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.
Chun Kwok WongDepartment of Chemical Pathology, Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0002-5637-8331
Elaine ChowDepartment of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.
Xing MingDepartment of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.
Huanyi CaoDepartment of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.
Ronald C MaDepartment of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.ORCID 0000-0002-1227-803X
Paul K S ChanDepartment of Medical Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.ORCID 0000-0002-6360-4608
Alice P S KongDepartment of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.
Joshua J X LiDepartment of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.
Guy A RutterDivision of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, United Kingdom.ORCID 0000-0001-6360-0343
Wing Hung TamDepartment of Obstetrics and Gynaecology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.ORCID 0000-0003-1189-740X
Juliana C N ChanDepartment of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China jchan@cuhk.edu.hk.ORCID 0000-0003-1325-1194
Chinese University of Hong Kong · HKNanyang Technological University · SG
Funding
Medical Research Council MR/J0003042/1Medical Research Council MR/L020149/1Medical Research Council MR/N00275X/1Medical Research Council MR/R022259/1Medical Research Council MR/S025618/1Wellcome TrustWellcome Trust 212625/Z/18/ZWellcome Trust WT098424AIA
Abstract
The herb dwarf lilyturf tuber (Maidong,
Indexed as
Plant ExtractsAnimalsCell LineDietary FatsI-kappa B KinaseInflammationInsulin-Secreting CellsInsulin SecretionInterleukin-1betaMiceObesityOphiopogonPlant TubersTranscription Factor RelADietary FatsI-kappa B KinaseIL1B protein, mouseInterleukin-1betaPlant ExtractsRela protein, mouseTranscription Factor RelAbeta celldiabetesinflammationinsulin secretionobesityOphiopogonis Radix
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT06978023ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.