Evidence map›Paper›PMID 32605603›Full record

ArticleAlzheimer's research & therapy2020

Community memory screening as a strategy for recruiting older adults into Alzheimer's disease research.

Guerry M Peavy, Cecily W Jenkins, Emily A Little, Christina Gigliotti, Amanda Calcetas, Steven D Edland, James B Brewer, Douglas Galasko, David P Salmon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Recommendations to address key recruitment challenges of Alzheimer's disease clinical trials.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Review
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Guerry M PeavyDepartment of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0948, USA. gpeavy@ucsd.edu.ORCID 0000-0001-7785-7916
Cecily W JenkinsDepartment of Neurology, Alzheimer Therapeutic Research Institute, University of Southern California, 9860 Mesa Rim Road, San Diego, CA, 92121, USA.
Emily A LittleDepartment of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0948, USA.
Christina GigliottiDepartment of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0948, USA.
Amanda CalcetasDepartment of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0948, USA.
Steven D EdlandDepartment of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0948, USA.
James B BrewerDepartment of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0948, USA.
Douglas GalaskoDepartment of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0948, USA.
David P SalmonDepartment of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0948, USA.
University of California San Diego · USUniversity of Southern California · US

Funding

UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Mark W Bondi · 2019 to 2026
$34.9M
NIA NIH HHS NIA P-30 AG062429NIA NIH HHS P30 AG062429
6 · The paper itself

Abstract

backgroundGrowing awareness of Alzheimer's disease (AD) has prompted a demand for quick and effective ways to screen for memory loss and cognitive decline in large numbers of individuals in the community. Periodic Memory Screening Day events provide free, brief cognitive screening aimed at those 65 years and older, and can serve as an opportunity to gauge participants' attitudes towards AD research and recruit them into ongoing research projects.

methodsOver 6 single-day events in 2 years, more than 574 individuals were individually screened using the MoCA and a story recall task (immediate and delayed), given feedback about their performance, and introduced to AD research and opportunities to participate.

resultsScreening classified 297 individuals (52.0%) as having "No Decline," 192 (33.6%) as "Possible decline," and 82 (14.4%) as "Likely decline." Those with "Likely decline" were older and less educated, had more memory concerns, were more likely to be men, and were less likely to have a positive family history of dementia than those with "No Decline." Subsequent validation of screening procedures against a full clinical evaluation showed 72% classification accuracy with a skew towards over-calling Possible and Likely decline and thereby guiding questionable individuals to a more thorough evaluation. Of those screened, 378 (66%) agreed to additional research and consented to being listed in a research registry, and a majority (70-85%) of those consenting reported they were amenable to various AD research procedures including lumbar puncture, MRI, and autopsy. Overall, 19.1% of those screened met inclusion criteria for ongoing studies and were successfully recruited into AD research.

conclusionsConducting a few concentrated community memory screening events each year may help meet the public's demand for brief assessment of memory concerns and can be a relatively effective and efficient recruitment strategy for AD research.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAgedHumansLongitudinal StudiesMaleMemoryMemory DisordersNeuropsychological TestsAlzheimer’s diseaseCognitionDementiaMemoryRecruitmentScreening

Identifiers

PMID32605603
PMCPMC7325657
OpenAlexW3040668147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.